生长抑素受体1，2在卵巢浆液性乳头状囊腺癌中的表达、分布及其相关性研究

发布时间：2018-06-25 16:39

本文选题：卵巢浆液性乳头状囊腺癌 + 生长抑素受体1　；参考：《山西医科大学》2015年硕士论文

【摘要】：目的:研究并讨论生长抑素受体1(SSTR1)、生长抑素受体2(SSTR2)在卵巢浆液性乳头状囊腺癌中的表达、分布及相关性的研究。方法:该实验采用免疫组化SP法进行SSTR1,SSTR2的检测,以其染色细胞数所占比例作为生长抑素受体表达的计量标准,描述SSTR1,SSTR2不同计量表达强度,采用SPSS17.0统计软件分析29例患者SSTR1,SSTR2的表达强度,SSTR1,SSTR2在同一病人的肿瘤组织之中的表达分布特点,以及SSTR1和SSTR2在表达上的相关性研究。结果:采用秩和检验分析SSTR1和SSTR2两组间的阳性表达情况,结果显示:Z=5.0017,P0.001,按照α=0.05水准,即SSTR1和SSTR2的阳性表达强度差别有统计学意义,可以认为两种表达的阳性结果不同。SSTR1的阳性表达高于SSTR2。比较SSTR1表达阳性情况下SSTR2的阳性情况是否不同,检验SSTR1和SSTR2的阳性表达情况是否一致,采用一致性检验;结果显示:Z=0.444,P=0.6568,说明两种SSTR表达的分布情况不具有一致性。将镜下观察计数染色细胞数资料用SPSS17.0统计软件分析,其资料不服从正态分布资料,所以采用spearman秩相关分析,结果显示r=-0.007,P=0.969,即SSTR1和SSTR2的表达强度无相关性。结论:1.SSTR1在卵巢浆液性乳头状囊腺癌中的高表达较SSTR2有显著差异,说明SSTR1在该肿瘤的发生发展过程中是一个普遍现象,其SSTRl在OSPC的发展过程中很可能是一个潜在的提示性指标;2.SSTR1和SSTR2二者在卵巢浆液性乳头状囊腺癌中的表达无相关性;3.在对卵巢浆液性乳头状囊腺癌的研究中,SSTR1和SSTR2这两种基因的表达分布不具一致性,说明其存在组织学分布上的异质性,所以在针对药物治疗该种肿瘤时,SSTR1、SSTR2应作为独立的因素进行药物靶点设计。
[Abstract]:Objective: to study the expression, distribution and correlation of somatostatin receptor 1 (SSTR1) and somatostatin receptor 2 (SSTR2) in ovarian serous papillary cystadenocarcinoma. Methods: SSTR1SSTR2 was detected by immunohistochemical SP method. The expression of somatostatin receptor was measured by the proportion of SSTR1SSTR2 staining cells, and the intensity of SSTR1SSTR2 expression was described. SPSS 17.0 statistical software was used to analyze the expression intensity of SSTR1 and SSTR2 in 29 patients and the expression distribution of SSTR1 and SSTR2 in tumor tissues of the same patient, and the correlation between SSTR1 and SSTR2 in the expression of SSTR1 and SSTR2. Results: the positive expression of SSTR1 and SSTR2 was analyzed by rank sum test. The results showed that the positive expression intensity of SSTR1 and SSTR2 was significantly different according to 伪 0.05 level. It can be concluded that the positive expression of SSTR1 is higher than that of SSTR2. The results showed that the positive expression of SSTR2 was different from that of SSTR1, and the positive expression of SSTR1 and SSTR2 was the same, and the results showed that the distribution of SSTR2 and SSTR1 were not consistent. The statistical software SPSS 17.0 was used to analyze the number of cells counted and stained under microscope. The data were not collected from normal distribution data, so spearman rank correlation analysis was used. The results showed that there was no correlation between the expression intensity of SSTR1 and SSTR2, and the correlation between the expression intensity of SSTR1 and SSTR2 was not found in the statistical software SPSS 17.0. The results showed that there was no correlation between SSTR1 and SSTR2. Conclusion the high expression of SSTR1 in ovarian serous papillary cystadenocarcinoma is significantly different from that in SSTR2, indicating that SSTR1 is a common phenomenon in the development of ovarian serous cystadenocarcinoma. The expression of SSTR1 and SSTR2 in ovarian serous papillary cystadenocarcinoma may be a potential indicator in the development of OSPC. 2. There is no correlation between SSTR1 and SSTR2 in ovarian serous papillary cystadenocarcinoma. In the study of ovarian serous papillary cystadenocarcinoma, the expression of SSTR1 and SSTR2 genes were not consistent, indicating the heterogeneity of histological distribution. Therefore, SSTR1 and SSTR2 should be used as independent factors in drug targeting.
【学位授予单位】：山西医科大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R737.31

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