7种血清肿瘤标志物对原发性卵巢癌患者的临床诊断研究

发布时间：2018-06-28 08:30

本文选题：血清肿瘤标志物 + 原发性卵巢癌　；参考：《检验医学与临床》2016年04期

【摘要】：目的研究7种血清肿瘤标志物对原发性卵巢癌患者的临床诊断效果。方法选取该院接受治疗的原发性卵巢癌患者、良性卵巢肿瘤患者、同期体检健康女性,各75例,分析7种血清肿瘤标志物对原发性卵巢癌患者的诊断效果。结果与良性卵巢肿瘤组和健康对照组比较,卵巢癌组患者血清人附睾分泌蛋白4(HE4)、糖类抗原125(CA125)、癌胚抗原(CEA)、糖类抗原199(CA199)、糖类抗原153(CA153)、甲胎蛋白(AFP)、人绒毛膜促性腺激素(β-hCG)等水平显著升高,差异有统计学意义(P0.05);与健康对照组比较,良性卵巢肿瘤组患者血清HE4、CA125、CEA、CA199、CA153等水平也显著升高,差异有统计学意义(P0.05)。血清HE4、CA125、CEA的敏感性与准确性最高;血清CA153、AFP、β-hCG的敏感性与准确性最低。血清HE4、CA125、CEA 3项指标联合检测的敏感性、特异性与准确性最高;血清HE4与CEA 2种指标联合检测的敏感性、特异性与准确性最低。结论联合检测原发性卵巢癌患者血清HE4、CA125、CEA肿瘤标志物,其敏感性、特异性、准确性最高,具有临床诊断价值。
[Abstract]:Objective to study the clinical diagnosis effect of 7 serum tumor markers in patients with primary ovarian cancer. Methods We selected 75 healthy women, 75 healthy women and 75 patients with ovarian cancer treated in our hospital. The diagnostic effect of 7 serum tumor markers on patients with primary ovarian cancer was analyzed. Results compared with benign ovarian tumor group and healthy control group, Serum levels of human epididymal secretory protein 4 (HE4), carbohydrate antigen 125 (CA125), carcinoembryonic antigen (CEA), carbohydrate antigen 199 (CA199), carbohydrate antigen 153 (CA153), alpha-fetoprotein (AFP), human chorionic gonadotropin (尾 -hCG) were significantly increased in patients with ovarian cancer (P0.05). The serum levels of HE4, CA125, CEA, CA199, CA153 and so on in patients with benign ovarian tumors were also significantly higher than those in patients with benign ovarian tumors (P0.05). The sensitivity and accuracy of serum HE4, CA125 and CEA were the highest, and the sensitivity and accuracy of serum CA153 and 尾 -hCG were the lowest. The sensitivity, specificity and accuracy of serum HE4 CA125 and CEA were the highest, and the sensitivity of serum HE4 and CEA were the lowest. Conclusion the combined detection of CEA in serum of patients with primary ovarian cancer has the highest sensitivity, specificity and accuracy, and is valuable for clinical diagnosis.
【作者单位】：江苏省泰兴市人民医院检验科;
【分类号】：R737.31;R730.43

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