CD73在卵巢上皮性癌组织中的表达及与肿瘤生长转移的相关性研究

发布时间：2018-06-28 21:13

本文选题：卵巢上皮性癌 + CD　；参考：《中国实验诊断学》2016年12期

【摘要】：目的检测卵巢上皮性癌中CD73的表达情况及微血管计数值,探讨CD73与卵巢上皮性癌发生、发展、转移的关系。方法利用免疫组化法及微血管计数法,检测正常卵巢组织,卵巢上皮性囊腺瘤,卵巢交界性上皮性囊腺瘤,卵巢上皮性囊腺癌中CD73的表达情况及微血管计数。分析卵巢上皮性癌中CD73表达程度及MVD计数与临床病理学参数的关系,并分析二者之间的关系。结果卵巢上皮性癌组织中CD73的表达程度及MVD计数均高于良性组及交界组(P0.05),二者与患者年龄、组织学分型无关,与临床分期、组织学分级、淋巴结浸润、腹水及腹腔冲洗液中癌细胞相关,并且二者之间的表达正相关。结论 CD73在肿瘤的发生机制中起到一定的作用;CD73与恶性肿瘤严重程度正相关,有望作为一个新的评估卵巢上皮性癌病情进展及预后的指标,为基因的靶向治疗提供了新的思路。
[Abstract]:Objective to detect the expression of CD73 and microvessel count in epithelial ovarian carcinoma, and to investigate the relationship between CD73 and occurrence, development and metastasis of epithelial ovarian carcinoma. Methods the expression of CD73 and microvessel count in normal ovarian tissue, ovarian epithelial cystadenoma, borderline epithelial ovarian cystadenoma and ovarian epithelial cystadenocarcinoma were detected by immunohistochemistry and microvessel counting. To analyze the relationship between the expression of CD73 and MVD and clinicopathological parameters in epithelial ovarian carcinoma. Results the expression of CD73 and MVD in epithelial ovarian carcinoma were higher than those in benign group and borderline group (P0.05). There was no correlation between CD73 expression and age, histological type, clinical stage, histological grade, lymph node infiltration. The expression of cancer cells in ascites and peritoneal lavage was positively correlated. Conclusion CD73 plays an important role in the pathogenesis of cancer. CD73 is positively correlated with the severity of malignant tumor. It is expected to be a new index to evaluate the progression and prognosis of epithelial ovarian carcinoma and provide a new approach for gene targeting therapy.
【作者单位】：吉林大学中日联谊医院妇产科;吉林大学中日联谊医院药剂科;
【基金】：吉林省科技发展计划项目(编号:20140414018GH)
【分类号】：R737.31

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