缺氧相关蛋白HIF-1α和CAIX在妊娠滋养细胞疾病中的表达

发布时间：2018-06-28 23:09

本文选题：妊娠滋养细胞疾病 + 缺氧　；参考：《西安交通大学学报(医学版)》2015年03期

【摘要】：目的探索缺氧诱导因子-1α(HIF-1α)和碳酸酐酶IX(CAIX)在妊娠滋养细胞疾病发生、发展中的作用。方法应用免疫组化S-P法检测32例正常早孕绒毛(NP)、33例葡萄胎(HM)和26例侵袭性葡萄胎(IM)组织中HIF-1α和CAIX的表达情况。结果 HIF-1α在NP、HM和IM中的阳性表达率分别为28.1%(9/32)、45.5%(15/33)和73.1%(19/26)。在IM中的表达水平明显高于HM组和NP组,差异具有统计学意义(P0.05);HM组与NP组差异无统计学意义(P0.05)。CAIX在NP、HM和IM中的阳性表达率分别为31.2%(10/32)、3.0%(1/33)、57.7%(15/26)。在IM中的表达水平明显高于HM组和NP组,差异具有统计学意义(P0.05);在HM组织中几乎呈阴性表达,与NP组差异具有统计学意义(P0.05)。HIF-1α和CAIX在IM中的表达无显著性关联(P0.05)。结论 HIF-1α和CAIX的表达水平随着滋养细胞恶性程度的增加而明显升高,提示两者可能与妊娠滋养细胞疾病的发生发展及恶性转化有关。
[Abstract]:Objective to investigate the role of hypoxia inducible factor-1 伪 (HIF-1 伪) and carbonic anhydrase IX (CAIX) in the development of gestational trophoblastic diseases. Methods Immunohistochemical S-P method was used to detect the expression of HIF-1 伪 and CAIX in 33 cases of hydatidiform mole (HM) and 26 cases of invasive hydatidiform mole (IM) in 32 cases of normal early pregnancy villi (NP) and 26 cases of invasive hydatidiform mole (IM). Results the positive expression rates of HIF-1 伪 in NPHM and IM were 28.1% (9 / 32), 45.5% (15 / 33) and 73.1% (19 / 26), respectively. The expression level of CAIX in IM was significantly higher than that in HM and NP (P0.05). The positive rates of CAIX in NPHM and IM were 31.2% (10 / 32) or 3.0% (1 / 33), 57.7% (15 / 26), respectively. The expression level in IM was significantly higher than that in HM group and NP group, the difference was statistically significant (P0.05), but almost negative expression in HM tissue, there was no significant correlation between HIF-1 伪 and CAIX expression in IM (P0.05). Conclusion the expression of HIF-1 伪 and CAIX increased with the increase of malignant degree of trophoblastic cells, suggesting that the expression of HIF-1 伪 and CAIX may be related to the occurrence, development and malignant transformation of gestational trophoblastic disease.
【作者单位】：西安交通大学医学部第一附属医院妇产科;西安市第四医院妇产科;
【基金】：国家自然科学基金资助(No.81172489)~~
【分类号】：R737.33

【参考文献】