亚临床甲状腺功能减退与妊娠期高血压疾病关系的探讨

发布时间：2018-06-29 04:54

本文选题：亚临床甲状腺功能减退 + 妊娠期高血压疾病　；参考：《中国妇产科临床杂志》2015年04期

【摘要】：目的探讨妊娠合并亚临床甲状腺功能减退(甲减)与妊娠期高血压疾病的关系。方法选择80例妊娠28~34周妊娠期高血压疾病患者(其中子痫前期40例,妊娠期高血压40例)作为研究组,40例正常孕妇作为对照组,比较两组血清促甲状腺激素(TSH)、游离甲状腺素(FT4)、甲状腺过氧化物酶抗体(TPOAb)及血脂等指标。结果子痫前期组、妊娠期高血压组患者血清TSH和TPOAb水平均高于对照组(P0.05),FT4水平低于对照组(P0.05);子痫前期组与妊娠期高血压组中亚临床甲减分别占27.5%(11/40)和25.0%(10/40),TPOAb阳性率分别为22.5%(9/40)和20.0%(8/40),均高于对照组(P0.05);妊娠期高血压疾病合并亚临床甲减患者血清总胆固醇(6.40±0.46)mmol/L、甘油三酯(2.42±0.42)mmol/L和低密度脂蛋白(3.80±0.25)mmol/L,均高于单纯妊娠期高血压疾病患者(P0.05)。结论妊娠期高血压疾病的发生可能与亚临床甲减相关,二者可能互为因果,并可能均与血脂代谢异常有关。
[Abstract]:Objective to investigate the relationship between subclinical hypothyroidism (hypothyroidism) and hypertensive disorder complicating pregnancy. Methods 80 patients with hypertensive disorder complicating pregnancy (40 preeclampsia and 40 gestational hypertension) were selected as the control group. Serum thyrotropin (TSH), free thyroxine (FT 4), thyroid peroxidase antibody (TPOAb) and blood lipid were compared between the two groups. Results in preeclampsia group, The serum levels of TSH and TPOAb in the hypertensive complicating pregnancy group were higher than those in the control group (P0.05) and FT4 levels were lower than those in the control group (P0.05), and the positive rates of subclinical hypothyroidism in preeclampsia group and gestational hypertension group were 27.5% (11 / 40) and 25.0% (10 / 40), respectively, which were 22. 5% (9 / 40) and 20. 0% (8 / 40) higher than those in the control group. Serum total cholesterol (6.40 卤0.46) mmol / L, triglyceride (2.42 卤0.42) mmol / L and low density lipoprotein (3.80 卤0.25) mmol / L in hypertensive disorder complicating pregnancy with subclinical hypothyroidism were significantly higher than those in hypertensive disorder complicating pregnancy (P0.05). Conclusion the occurrence of hypertensive disorder complicating pregnancy may be related to subclinical hypothyroidism and may be causality and may be related to dyslipidemia.
【作者单位】：湖南省妇幼保健院产科;
【分类号】：R581.2;R714.256

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