外周血中细胞因子表达水平与孕妇胎膜早破及新生儿围产期感染的相关性研究
发布时间：2018-06-30 06:03
本文选题：细胞因子 + 胎膜早破 ； 参考：《中华医院感染学杂志》2017年19期
【摘要】：目的分析外周血细胞因子在胎膜早破(PROM)、新生儿围产期感染中表达特点以及临床意义。方法选取2014年6月-2015年7月在医院确诊为足月胎膜早破并成功分娩的132例孕妇作为胎膜早破组,选取同期足月正常分娩的130名孕妇作为正常对照组,孕妇在分娩前、分娩后24h内空腹抽取外周静脉血,新生儿在出生后24h内抽取外周静脉血,应用免疫学方法检测血清可溶性白细胞分化抗原14(SCD14)、降钙素原(PCT)、C-反应蛋白(CRP)、干扰素-γ(IFN-γ)以及白细胞介素-10(IL-10)水平,同时统计新生儿围产期感染情况,对比分析正常孕妇与胎膜早破孕妇、围产期感染新生儿与健康新生儿之间外周血细胞因子表达水平的差异性。结果胎膜早破组分娩后SCD14(46.34±8.35)ng/ml、PCT(52.36±8.23)pg/ml、CRP(4.78±1.24)mg/ml、IFN-γ(75.24±9.23)pg/ml、IL-10(6.59±1.25)pg/ml显著下降,两组孕妇外周血清SCD14、PCT、CRP、IFN-γ、IL-10差异有统计学意义(P0.05);胎膜早破组新生儿外周SCD14(56.35±8.25)ng/ml、PCT(55.32±10.24)pg/ml、CRP(6.01±1.69)mg/ml、IFN-γ(62.21±9.25)pg/ml、新生儿感染率15.15%显著高于正常对照组(P0.05),IL-10(5.26±1.02)pg/ml显著低于对照组(P0.05);PROM组感染新生儿外周血SCD14(63.52±9.25)ng/ml、PCT(61.32±1.24)pg/ml、CRP(7.26±1.75)mg/ml、IFN-γ(96.73±11.26)pg/ml显著高于未感染新生儿,而IL-10(4.03±2.01)pg/ml显著低于未感染新生儿(P0.05)。结论胎膜早破孕妇和新生儿围产期感染患儿的外周血炎性细胞因子表达水平显著升高,积极进行外周血炎性因子表达检测有利于早期预测胎膜早破和新生儿围产期感染。
[Abstract]:Objective to analyze the expression and clinical significance of peripheral blood cytokines in premature rupture of membranes (prom) and perinatal infection. Methods 132 pregnant women diagnosed in hospital from June 2014 to July 2015 were selected as the group of premature rupture of membranes and 130 pregnant women in the same period of term normal delivery as normal control group. The peripheral venous blood was drawn within 24 hours after delivery on an empty stomach, and the peripheral vein blood was taken from the newborn within 24 hours after birth. The levels of serum soluble leukocyte differentiation antigen 14 (SCD14), procalcitonin (PCT) C-reactive protein (CRP), interferon- 纬 (IFN- 纬) and interleukin-10 (IL-10) were detected by immunological method. The levels of cytokines in peripheral blood of normal pregnant women, premature rupture of membranes, perinatal infection newborns and healthy neonates were compared and analyzed. Results SCD14 (46.34 卤8.35) ng / ml PCT (52.36 卤8.23) PG / ml / ml CRP (4.78 卤1.24) mg / ml IFN- 纬 (75.24 卤9.23) PG / ml / L IL-10 (6.59 卤1.25) pg/ml decreased significantly after delivery in the premature rupture of membranes group. 涓ょ粍瀛曞澶栧懆琛，
本文编号：2085232
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