孕中期妊娠期糖尿病孕妇血清铁、锌和铁蛋白的变化情况及其与糖代谢指标的相关性
发布时间:2018-07-01 17:34
本文选题:妊娠期糖尿病 + 孕中期 ; 参考:《中国现代医学杂志》2017年10期
【摘要】:目的研究孕中期妊娠期糖尿病孕妇血清铁、锌和铁蛋白的变化情况,探讨其与妊娠期糖尿病发病的关系。方法选择2014年1月-2015年12月该院24~28周妊娠期糖尿病孕妇200例作为妊娠期糖尿病组,血糖正常孕妇200例作为对照组。观察两组孕妇血清铁蛋白、血清铁、血清锌水平及其与糖代谢指标的相关性,比较两组妊娠期铁缺乏、缺铁性贫血及胎儿发育情况。结果妊娠期糖尿病组孕妇空腹血糖(5.25±3.21)mmol/L、1 h血糖(10.56±1.73)mmol/L、2 h血糖(8.51±0.87)mmol/L、空腹胰岛素(13.12±2.24)mmol/L、糖化血红蛋白(6.97%)、胰岛素抵抗指数(2.98)均高于对照组(4.29±1.05)mmol/L、(8.72±1.24)mmol/L、(6.98±0.82)mmol/L、(6.46±1.87)mmol/L、(4.26%)、(1.19)(P0.05),妊娠期糖尿病组胰岛β细胞分泌功能(147.87)低于对照组(164.50)(P0.05)。妊娠期糖尿病组患者血清铁(27.34±7.12)μmol/L和铁蛋白(59.16±5.78)ng/ml水平高于对照组(20.98±6.01)μmol/L和(40.43±4.87)ng/ml(P0.05),妊娠期糖尿病组患者血清锌(10.59±2.23)μmol/L水平低于对照组(14.02±2.43)μmol/L(P0.05)。血清铁蛋白和血清铁与空腹血糖、空腹胰岛素、糖化血红蛋白、胰岛素抵抗指数均呈正相关(P0.05)。血清锌和空腹血糖、空腹胰岛素、糖化血红蛋白、胰岛素抵抗指数均呈负相关(P0.05)。两组妊娠期铁缺乏、缺铁性贫血的发生率差异无统计学意义(P0.05),两组胎儿双顶径、股骨长、头围、腹围差异无统计学意义(P0.05)。结论孕中期妊娠期糖尿病孕妇血清铁和铁蛋白水平升高,血清锌水平下降,血清铁、锌、铁蛋白水平与妊娠期糖尿病孕妇的糖代谢指标有相关性,和妊娠期糖尿病的发病有关。
[Abstract]:Objective to study the changes of serum iron, zinc and ferritin in pregnant women with gestational diabetes mellitus (M2DM), and to explore the relationship between them and the pathogenesis of gestational diabetes mellitus (GDM). Methods from January 2014 to December 2015, 200 pregnant women with gestational diabetes mellitus were selected as gestational diabetes mellitus group and 200 normal pregnant women as control group. The levels of serum ferritin, serum iron, serum zinc and their correlation with glucose metabolism were observed, and the iron deficiency, iron deficiency anemia and fetal development were compared between the two groups. 缁撴灉濡婂鏈熺硸灏跨梾缁勫瓡濡囩┖鑵硅绯,
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