左炔诺孕酮宫内释放系统对胰岛素样生长因子-1的影响与预防盆腔炎的相关性研究

发布时间：2018-07-01 21:22

本文选题：左炔诺孕酮宫内系统 + 胰岛素样生长因子　；参考：《中国工程科学》2015年06期

【摘要】：目的:研究左炔诺孕酮宫内释放系统对子宫内膜组织胰岛素样生长因子-1(IGF-1)的影响及预防盆腔炎疗效分析。方法:选取2010 2013年在嘉兴市妇幼保健院行宫腔镜下子宫内膜息肉切除术患者450例进行随机分组,研究组术后子宫内即时放置左炔诺孕酮宫内释放系统,而对照组不予放置。分别对术前及术后6个月子宫内膜组织IGF-1的表达情况进行对比,且随访2年,了解患者盆腔炎发生情况。结果:所有手术均成功,研究组子宫内膜组织IGF-1表达术后明显低于术前,对照组术前及术后子宫内膜组织IGF-1表达变化无差异,二组相比,术后IGF-1表达差异有显著性。随访2年对照组224例患者中39例发生盆腔炎,复发率为10.89%,而研究组184例发生盆腔炎12例,差异有显著性;研究组子宫内膜厚度术后明显小于术前,差异有显著性,对照组子宫内膜厚度术后与术前变化无差异性。结论:左炔诺孕酮宫内释放系统对子宫内膜的IGF-1表达存在抑制作用,可能是其抑制子宫内膜增生并减少盆腔炎发生的机制之一。
[Abstract]:Aim: to study the effect of levonorgestrel intrauterine release system on insulin-like growth factor-1 (IGF-1) in endometrial tissue and its effect on the prevention of pelvic inflammatory disease. Methods: 450 cases of endometrial polyp resection under hysteroscope were randomly divided into two groups in 2010 ~ 2013 in Jiaxing City Maternal and Child Health Hospital. The study group was treated with levonorgestrel intrauterine release system immediately after operation, while the control group was not. The expression of IGF-1 in endometrium was compared before and 6 months after operation and followed up for 2 years to understand the incidence of pelvic inflammatory disease. Results: all the operations were successful. The expression of IGF-1 in endometrium of study group was significantly lower than that of pre-operation, while the expression of IGF-1 in endometrium of control group had no difference before and after operation, and there was a significant difference between the two groups in the expression of IGF-1 after operation. In the control group, 39 cases developed pelvic inflammatory disease, the recurrence rate was 10.89, while the study group had 184 cases of pelvic inflammatory disease, the difference was significant, the thickness of endometrium in the study group was significantly lower than that before operation, the difference was significant. The change of endometrial thickness in control group was not different from that before operation. Conclusion: levonorgestrel intrauterine release system can inhibit the expression of IGF-1 in endometrium, which may be one of the mechanisms of inhibiting endometrial hyperplasia and reducing the incidence of pelvic inflammatory disease.
【作者单位】：嘉兴市妇幼保健院妇科;
【基金】：浙江省医药卫生科技项目(2010KYB108)
【分类号】：R713

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