七氟烷联合丙泊酚对老年腹腔镜宫颈癌切除术患者术后认知功能及血清SOD水平影响研究

发布时间：2018-07-03 01:02

  本文选题：老年宫颈癌 + 腹腔镜宫颈癌切除术　； 参考：《中国现代医学杂志》2017年19期

【摘要】：目的评价七氟烷联合丙泊酚对老年腹腔镜宫颈癌切除术患者术后认知功能及血清SOD水平影响研究。方法 60例老年宫颈癌患者随机分为对照组及试验组,各30例。所有患者均给予腹腔镜下宫颈癌切除术治疗,对照组给予1%~3%的七氟烷吸入进行麻醉维持;试验组在对照组基础上加用丙泊酚3.0 mg/(kg·h)靶控输注。比较两组患者手术前后血清中枢神经特异蛋白(S100β)、超氧化物歧化酶(SOD)、丙二醛(MDA)水平、简易智能精神状态量表(MMSE)评分及安全性。结果治疗后,与对照组比较,试验组患者血清SOD水平较高,MDA水平较低(P0.05)。试验组患者血清S100β水平较低,MMSE评分较高(P0.05)。两组患者不良反应发生率差异无统计学意义(P0.05)。结论七氟烷联合丙泊酚能够防止血清SOD水平下降,减轻氧化应激反应,对老年腹腔镜宫颈癌切除术患者术后认知功能的影响较小,且安全性较高。
[Abstract]:Objective to evaluate the effect of sevoflurane combined with propofol on cognitive function and serum SOD level in elderly patients undergoing laparoscopic cervical cancer resection. Methods 60 elderly patients with cervical cancer were randomly divided into control group and experimental group with 30 cases each. All the patients were treated with laparoscopic cervical cancer resection, the control group was treated with 1% sevoflurane inhalation for anesthesia maintenance, and the experimental group was given propofol 3.0 mg/ (kg h) target controlled infusion on the basis of the control group. The serum levels of central nervous specific protein (S100 尾), superoxide dismutase (SOD), malondialdehyde (MDA), simple mental state scale (MMSE) and safety were compared between the two groups before and after operation. Results after treatment, compared with the control group, the serum SOD level in the experimental group was higher than that in the control group (P0.05). The serum S 100 尾 level in the trial group was lower and MMSE score was higher (P 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P0.05). Conclusion sevoflurane combined with propofol can prevent the decrease of serum SOD level and alleviate oxidative stress reaction. It has little effect on cognitive function of elderly patients undergoing laparoscopic cervical cancer resection and is more safe.
【作者单位】： 承德医学院附属医院麻醉科;河北承钢职工医院麻醉科;河北兴隆县人民医院麻醉科;
【分类号】：R614;R737.33
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