卵巢癌组织中PTEN和P53蛋白的表达及其与卵巢癌临床特点的关系

发布时间：2018-07-03 09:47

  本文选题：卵巢肿瘤 + p　； 参考：《重庆医学》2017年02期

【摘要】：目的对卵巢癌组织中PTEN和P53蛋白的表达情况进行研究,探讨其与卵巢癌临床特点的关系。方法选择2013年12月至2014年12月吉林大学第一医院肿瘤妇科手术切除卵巢上皮癌标本50例和正常卵巢组织标本50例作为研究对象,免疫组织化学染色法测定组织中PTEN和P53的表达情况,观察卵巢癌组织中PTEN和P53的表达和卵巢癌临床特点的关系。结果卵巢癌组织中PTEN阳性率明显低于正常卵巢组织(P0.05),P53阳性率明显高于正常卵巢组织(P0.05)。卵巢癌Ⅱ期和Ⅲ~Ⅳ期的PTEN阳性率明显低于Ⅰ期,高分化卵巢癌组织中PTEN阳性率明显高于低分化和中分化卵巢癌组织(P0.05)。卵巢癌Ⅱ期和Ⅲ~Ⅳ期的P53阳性率明显高于Ⅰ期(P0.05),低分化卵巢癌组织中P53阳性率明显高于中分化和高分化卵巢癌组织(P0.05)。结论卵巢癌组织中PTEN表达降低,P53表达升高,PTEN和P53的表达和卵巢癌的临床分期及分化程度关系密切。
[Abstract]:Objective to study the expression of PTEN and p53 protein in ovarian cancer and its relationship with the clinical features of ovarian cancer. Methods from December 2013 to December 2014, 50 cases of ovarian epithelial carcinoma and 50 cases of normal ovarian tissue were selected from the first Hospital of Jilin University. The expression of PTEN and p53 was detected by immunohistochemical staining, and the relationship between the expression of PTEN and p53 and the clinical characteristics of ovarian cancer was observed. Results the positive rate of PTEN in ovarian cancer tissue was significantly lower than that in normal ovarian tissue (P0.05) and the positive rate of p53 was significantly higher than that in normal ovarian tissue (P0.05). The positive rate of PTEN in stage 鈪，

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