卵巢癌患者血清唾液酸含量检测的价值

发布时间：2018-07-04 14:49

本文选题：妇科肿瘤 + 卵巢癌　；参考：《中国癌症杂志》2017年07期

【摘要】：背景与目的:目前临床上用于辅助诊断卵巢癌的血清标志物相对缺乏。该研究旨在探讨血清唾液酸(sialic acid,SA)含量检测在卵巢癌患者的辅助诊断、疗效监测等中的临床应用价值。方法:采用酶法检测332例妇科恶性肿瘤患者、230例妇科良性疾病患者及194名健康对照者的血清SA含量;同时采用化学发光法检测上述标本的血清CA125及HE4含量。结果:妇科恶性肿瘤患者的血清SA含量为584.0(499.8,702.5)mg/L,明显高于妇科良性疾病组[497.0(454.0,559.0)mg/L]及健康对照组[475.0(443.8,505.0)mg/L,P0.05];其中卵巢癌组血清SA含量最高[675.0(582.0,816.0)mg/L];血清SA联合CA125检测对卵巢恶性肿瘤的灵敏度高达95.17%,阴性预测值为94.37%;卵巢癌患者随访测定过程中,血清SA含量随着病情的好转,其浓度逐步降低。结论:血清SA含量检测可应用于卵巢癌的早期筛查、鉴别诊断及疗效监测。
[Abstract]:Background & objective: there is a relative lack of serum markers for the diagnosis of ovarian cancer. The purpose of this study was to evaluate the clinical value of serum sialic acidine SA in the diagnosis and therapeutic monitoring of ovarian cancer. Methods: the serum SA levels of 332 patients with gynecologic malignant tumors and 194 healthy controls were measured by enzyme method, and the serum levels of CA125 and HE4 were detected by chemiluminescence method. Results: the serum SA content of gynecological malignant tumor patients was 584.0 (499.8702.5) mg / L, which was significantly higher than that of benign gynecological disease group [497.0 (454.0559.0) mg / L] and healthy control group [475.0 (443.8505.0) mg / L P 0.05], the serum SA level of ovarian cancer group was the highest [675.0 (582.0816.0) mg / L], and the sensitivity of serum SA combined with CA125 detection to ovarian malignant tumor was higher than that of healthy control group [497.0 (454.0559.0) mg / L] and healthy control group [475.0 (443.8505.0) mg / L P 0.05]. The degree of ovarian cancer was 95.17 and the negative predictive value was 94.37. The concentration of serum SA decreased gradually with the improvement of the condition. Conclusion: serum SA level can be used for early screening, differential diagnosis and monitoring of curative effect of ovarian cancer.
【作者单位】：复旦大学附属肿瘤医院检验科复旦大学上海医学院肿瘤学系;
【分类号】：R730.43;R737.31

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