醋酸棉酚宫内给药装置治疗子宫腺肌病实验研究

发布时间：2018-07-05 00:10

本文选题：子宫腺肌病 + 宫内节育器　；参考：《中国实用妇科与产科杂志》2017年02期

【摘要】：目的探讨宫内醋酸棉酚给药装置治疗实验性子宫腺肌病的可行性与安全性。方法采用ICR小鼠异体垂体移植法成功建立子宫腺肌病模型4个月后,模型小鼠子宫内给予3种不同剂量的醋酸棉酚治疗2个月后,测定ICR小鼠醋酸棉酚血浆浓度、病灶大体结节个数以及组织学HE染色评分分数,并与每日灌胃治疗以及对照组比较。结果模型结节数目与HE染色评分分数随着ICR小鼠宫内局部醋酸棉酚的治疗剂量增加而逐渐下降;当宫内醋酸棉酚剂量增加到每20 g体重0.2 mg时,模型结节数目与病灶HE染色评分分数两者差异均有统计学意义(P0.05)。另外,与灌胃组比较,宫内局部给药组的血浆醋酸棉酚浓度低且稳定。结论宫内局部给药装置携带合适剂量的醋酸棉酚治疗实验性小鼠模型子宫腺肌病是安全可行的。
[Abstract]:Objective to investigate the feasibility and safety of intrauterine gossypol acetate in the treatment of experimental adenomyosis. Methods the adenomyosis model of ICR mice was successfully established by allogeneic pituitary transplantation for 4 months. After 3 different doses of gossypol acetate were given to the model mice for 2 months, the plasma concentration of gossypol acetate in ICR mice was measured. The number of gross nodules and the score of histological HE staining were compared with those of daily gastric perfusion and control group. Results the number of model nodules and the score of HE staining decreased with the increase of intrauterine dose of gossypol acetate in ICR mice, when the dose of gossypol acetate increased to 0.2 mg per 20 g body weight. There was significant difference between the number of model nodules and HE staining score (P0.05). In addition, plasma gossypol concentration in intrauterine administration group was lower and stable than that in intrauterine administration group. Conclusion it is safe and feasible to carry appropriate dosage of gossypol acetate in intrauterine administration device for the treatment of experimental mouse model of adenomyosis.
【作者单位】：杭州师范大学附属医院妇产科;浙江大学医学院附属妇产科医院妇科;
【基金】：浙江省中医药科技项目(2007CA074) 浙江省公益性技术应用研究专项基金(2013C33149)
【分类号】：R711.71

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