3例子宫体原发性非霍奇金淋巴瘤的临床病理观察

发布时间：2018-07-05 03:36

本文选题：淋巴瘤 + 非霍奇金　；参考：《重庆医学》2017年14期

【摘要】：目的探讨3例原发于子宫体非霍奇金淋巴瘤(NHL)临床病理特点。方法收集3例原发于子宫体NHL的临床病理资料,采用免疫组织化学方法标记肿瘤细胞,按最新WHO淋巴造血组织肿瘤分类进行组织学分型,并与子宫其他疾病进行鉴别诊断。结果 3个病例均以异常阴道排液或出血为首发症状就诊,临床及病理都误诊为子宫常见疾病。子宫标本组织病理显示:病例1肿瘤细胞表达CD3、CD56及TiA-1等抗原,且EBV病毒表达阳性,支持NK/T细胞淋巴瘤的诊断。病例2和病例3肿瘤细胞表达B细胞特异抗原标记CD20等,肿瘤细胞体积为淋巴细胞的3倍,增殖指数高,支持弥漫性大B细胞淋巴瘤的诊断。结论 3例病例镜下肿瘤细胞似淋巴细胞样,弥漫浸润子宫内膜及肌壁间,与子宫内膜间质肉瘤等难以鉴别,需借助免疫组织化学方法进行确诊及鉴别诊断。
[Abstract]:Objective to investigate the clinicopathological features of 3 cases of primary non-Hodgkin's lymphoma (NHL) in the uterus. Methods the clinicopathological data of 3 cases of primary NHL in uterine body were collected. The tumor cells were labeled with immunohistochemical method. Histological classification was performed according to the latest WHO classification of lymphoid hematopoietic tumors, and differential diagnosis was made between NHL and other uterine diseases. Results the first symptoms of the three cases were abnormal vaginal effusion or hemorrhage, and the clinical and pathological diagnosis were misdiagnosed as common uterine diseases. Histopathological findings of uterine specimens showed that tumor cells in case 1 expressed CD3 + CD56 and TiA-1 antigens, and EBV virus was positive, which supported the diagnosis of NKR / T cell lymphoma. Cases 2 and 3 showed that tumor cells expressed B cell specific antigen labeled CD20 and the tumor cells were 3 times larger than lymphocytes and had high proliferative index which supported the diagnosis of diffuse large B cell lymphoma. Conclusion the tumor cells in 3 cases were lymphocyte-like and diffusely infiltrated the endometrium and muscle wall. It was difficult to distinguish them from endometrial stromal sarcoma. The diagnosis and differential diagnosis should be made by immunohistochemical method.
【作者单位】：南昌大学第一附属医院病理科;
【分类号】：R737.33

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