卵泡液中双酚A在多囊卵巢综合征发病中的作用及相关因素探讨

发布时间：2018-07-05 06:09

  本文选题：双酚A(BPA) + 卵泡液　； 参考：《生殖与避孕》2016年07期

【摘要】：目的:探讨卵泡液中双酚A(bisphenol A,BPA)在多囊卵巢综合征(PCOS)发病中的作用。方法:于取卵日收集行体外受精/卵胞质内单精子显微注射(IVF/ICSI)的PCOS患者和非PCOS患者的卵泡液,检测患者卵泡液BPA水平和卵泡液性激素水平,并进一步与患者血清抗苗勒氏管激素(AMH)及临床结局等因素行相关性分析。结果:PCOS患者和非PCOS患者的卵泡液BPA水平(446.57±63.57 ng/L vs 336.29±59.02 ng/L,P0.001)、血清AMH水平(12.09±4.78μg/L vs5.69±2.98μg/L,P0.001)、卵泡液FSH(5.58±1.66 IU/L vs 3.95±1.54 IU/L,P=0.008)、LH(4.54±2.97 IU/L vs 0.96±1.10 IU/L,P0.001)和T(54.68±34.34 nmol/L vs 32.48±16.68 nmol/L,P=0.035)组间比较有统计学差异。相关性分析显示,卵泡液中BPA水平与血清AMH水平呈显著正相关(r=0.577,P=0.001)。结论:卵巢局部的BPA暴露可能参与了PCOS疾病的发生、发展。
[Abstract]:Objective: to investigate the role of bisphenol A (bisphenol A) in the pathogenesis of polycystic ovary syndrome (PCOS). Methods: follicular fluid was collected from PCOS patients and non-PCOS patients who underwent in vitro fertilization / intracytoplasmic sperm microinjection (IVF / ICSI) on the day of in vitro fertilization / intracytoplasmic sperm injection (IVF / ICSI). The relationship between AMH and clinical outcome was analyzed. 缁撴灉:PCOS鎮ｈ，

本文编号：2099235