妊娠期糖尿病孕妇血清ω-3脂肪酸与胰岛素抵抗关系的研究

发布时间：2018-07-09 23:44

本文选题：ω-脂肪酸 + 糖尿病　；参考：《现代预防医学》2015年12期

【摘要】：目的探究妊娠期糖尿病孕妇空腹血清ω-3脂肪酸水平对胰岛素抵抗的影响。方法测定40例妊娠期糖尿病孕妇(GDM组)、40例正常妊娠孕妇(正常妊娠组)空腹血清ω-3脂肪酸、胰岛素、血糖、糖化血红蛋白(Hb A1c)水平;并计算2组孕妇胰岛素抵抗指数(Insulin Resistance IRI)。结果 GDM组孕妇空腹血清ω-3脂肪酸水平较正常妊娠组明显减少,2组比较差异有统计学意义(t=26.78,P0.05);GDM组孕妇IRI、空腹血糖、胰岛素、Hb A1c水平明显高于正常妊娠组,2组比较差异有统计学意义(t=32.56,t=18.25,t=15.31,t=13.24,P0.05)。(2)GDM组孕妇血清ω-3脂肪酸水平与IRI、空腹血糖、Hb A1c呈负相关(r=-0.812,r=-0.545,r=-0.296,P0.05),与胰岛素水平无相关性(r=0.197,P0.05)。正常妊娠组孕妇血清ω-3脂肪酸与IRI呈负相关,(r=-0.280,P0.05),相关性小于GDM组,正常妊娠组孕妇ω-3脂肪酸水平与胰岛素、血糖、Hb A1c无相关性(r=0.213、0.179、0.195)。结论提高GDM孕妇血清ω-3脂肪酸含量可减轻其胰岛素抵抗的程度。
[Abstract]:Objective to investigate the effect of fasting serum omega-3 fatty acid level on insulin resistance in pregnant women with gestational diabetes mellitus. Methods the fasting serum levels of omega-3 fatty acid, insulin, blood glucose and HbA1c were measured in 40 pregnant women with gestational diabetes mellitus (GDM group) and 40 normal pregnant women (normal pregnancy group), and the insulin resistance IRI was calculated. Results the fasting serum omega-3 fatty acid level in GDM group was significantly lower than that in normal pregnancy group. The level of serum omega-3 fatty acid in GDM group was significantly higher than that in normal pregnancy group (P 0.05). There was a negative correlation between serum omega-3 fatty acid level and IRI, fasting blood glucose level and HbA1c level (r -0.812r-0.545r-0.296p 0.05), but no correlation with insulin level (r 0.197). There was a negative correlation between serum 蠅 -3 fatty acids and IRI in normal pregnancy group (r = 0.280), which was lower than that in GDM group. There was no correlation between omega-3 fatty acid level and insulin and blood glucose HbA1c in normal pregnant women (r = 0.213 卤0.179 卤0.195). Conclusion increasing the content of omega-3 fatty acids in serum of GDM pregnant women can reduce the degree of insulin resistance.
【作者单位】：石河子大学第一附属医院妇产科;
【基金】：科技部国家级科技惠民计划(2013GS650104)
【分类号】：R714.256

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