子宫内膜癌组织中uPA及Cath-D的表达及意义

发布时间：2018-07-10 00:53

本文选题：子宫内膜肿瘤 + 尿激酶型纤溶酶原激活剂　；参考：《青岛大学》2014年硕士论文

【摘要】：目的检测子宫内膜癌组织中尿激酶型纤溶酶原激活物(uPA)以及组织蛋白酶D(Cath-D)的表达并探讨两者的相关性及临床意义。方法采用免疫组织化学方法(PV-6000二步法)检测31例子宫内膜癌组织(子宫内膜癌组)、17例子宫内膜增生组织(子宫内膜增生组)及10例正常子宫内膜组织(正常对照组)中uPA及Cath-D的表达,分析探讨其与子宫内膜癌手术临床病理分期、组织学分级及肌层浸润深度的关系,并探讨两者表达的相关性。结果 1.子宫内膜癌组中uPA和Cath-D的表达均高于子宫内膜增生组及正常对照组中的表达,差异均有统计学意义(P0.05);而在子宫内膜增生组中的表达与正常对照组差异无统计学意义(P0.05)。 2.uPA以及Cath-D的阳性表达与子宫内膜癌的临床病理分期、组织学分级及肌层浸润深度有关,差异均具有统计学意义(P0.05)。 3.子宫内膜癌组中uPA和Cath-D的阳性表达呈正相关(r=0.673,P0.05) 结论 1.子宫内膜癌组织中uPA、Cath-D的高表达与子宫内膜癌的发生、侵袭、转移和预后密切相关。 2.uPA和Cath-D在子宫内膜癌组织中的表达有较高的一致性。提示uPA和Cath-D在子宫内膜癌的发生发展侵袭转移过程中可能起着协同和互相调节的作用,两者的联合检测可有助于成为判断子宫内膜癌的发展及预后的重要指标。
[Abstract]:Objective to detect the expression of urokinase type plasminogen activator (UPA) and cathepsin D (Cath-D) in endometrial carcinoma and to explore their correlation and clinical significance. Methods 31 cases of endometrial carcinoma (endometrial carcinoma group) and 17 cases of endometrial hyperplasia (endometrial hyperplasia group) and 10 cases of normal endometrial tissue were detected by immunohistochemical method (PV-6000 two-step method). The expression of UPA and Cath-D in normal control group, To investigate the relationship between the expression of endometrial carcinoma and the clinicopathologic stage, histological grade and depth of myometrial invasion. Result 1. The expression of UPA and Cath-D in endometrial carcinoma group was higher than that in endometrial hyperplasia group and normal control group. The expression of UPA and Cath-D in endometrial hyperplasia group was not significantly different from that in normal control group (P0.05). 2. The positive expression of UPA and Cath-D and the clinicopathologic stage of endometrial carcinoma. Histological grading and depth of myometrial infiltration were significantly different (P0.05). There was a positive correlation between UPA and Cath-D expression in endometrial carcinoma group (r 0.673 P 0.05). Conclusion 1. The high expression of Cath-D in endometrial carcinoma is closely related to the occurrence, invasion, metastasis and prognosis of endometrial carcinoma. 2. The expression of UPA and Cath-D in endometrial carcinoma is highly consistent. These results suggest that UPA and Cath-D may play a synergistic and interregulatory role in the development, invasion and metastasis of endometrial carcinoma. The combined detection of UPA and Cath-D may be an important index to judge the development and prognosis of endometrial carcinoma.
【学位授予单位】：青岛大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R737.33

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