脂联素与妊娠期糖尿病危险因素筛查

发布时间：2018-07-10 02:58

本文选题：妊娠 + 糖尿病　；参考：《郑州大学学报(医学版)》2015年05期

【摘要】：目的:探讨妊娠期糖尿病(GDM)患者血清脂联素水平变化,并筛查GDM发生的危险因素。方法:采用ELISA法测定35例GDM患者、40例正常妊娠妇女(NGT组)血清脂联素水平,结合其他临床和生化指标,筛查GDM发生的危险因素。结果:GDM组脂联素水平较NGT组降低(t=7.763,P0.001);logistic回归分析显示孕前BMI增高[OR(95%CI)=4.799(1.296~17.777)]及孕期脂联素水平降低[OR(95%CI)=0.238(0.085~0.666)]为GDM发生的危险因素;ROC曲线显示GDM发生的预测因素为孕前BMI(曲线下面积0.811,P0.001)、糖尿病家族史(曲线下面积0.729,P0.001)、孕期脂联素(曲线下面积0.694,P=0.007)。结论:孕前筛查糖尿病家族史、BMI可提前预测GDM的发生,并为辅助诊断提供依据;孕期脂联素水平降低为GDM发生的危险因素;脂联素可望成为GDM治疗的新药。
[Abstract]:Objective: to investigate the changes of serum adiponectin levels in gestational diabetes mellitus (GDM) and to screen the risk factors for GDM. Methods: serum adiponectin levels in 35 GDM patients and 40 normal pregnant women (NGT group) were determined by Elisa, and the risk factors of GDM were screened by combining with other clinical and biochemical indexes. Results compared with NGT group, the weight of adiponectin in GDM group was lower than that in NGT group. Logistic regression analysis showed that BMI increased before pregnancy [OR (95CI) 4.799 (1.296 卤17.777)] and decreased adiponectin level during pregnancy [OR (95CI) 0.238 (0.0855.666)] were risk factors of GDM. ROC curve showed that the predictor of GDM was pre-gestational BMI (area under the curve 0.811P0.001). Family history of diabetes mellitus (area under the curve 0.729 P 0.001) and adiponectin during pregnancy (area under the curve 0.694m P0. 007). Conclusion: screening family history of diabetes before pregnancy and BMI can predict the occurrence of GDM in advance and provide evidence for auxiliary diagnosis. The decrease of adiponectin level in pregnancy is the risk factor of GDM. Adiponectin is expected to be a new drug in the treatment of GDM.
【作者单位】：河南中医学院基础医学院病理与病理生理学学科;郑州大学第二附属医院内分泌科;
【基金】：河南省科技发展计划132300410156 河南省卫生厅重点项目201002010
【分类号】：R714.256

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