妊娠糖尿病患者血浆甘丙肽的表达及意义

发布时间：2018-07-10 15:55

本文选题：甘丙肽 + 胰岛素抵抗　；参考：《广东医学》2015年03期

【摘要】：目的探讨妊娠糖尿病(GDM)患者妊娠中期血浆甘丙肽(GAL)水平与糖代谢及胰岛素抵抗的关系。方法选取40例GDM患者和40例妊娠糖耐量正常(NGT)者,分别检测其血浆GAL、空腹胰岛素、空腹血糖及服糖后1、2 h的血糖及胰岛素水平,计算胰岛素抵抗及胰岛素敏感指数。结果 GDM患者妊娠中期血浆GAL水平显著高于NGT者,并且GAL与体质指数、空腹血糖、餐后1 h血糖呈显著正相关,与胰岛素敏感指数呈显著负相关。结论 GDM患者血浆中GAL表达水平显著升高,并且与GDM期间空腹血糖水平改变、餐后1 h血糖水平、胰岛素敏感性下降及体质指数变化密切相关,高表达的GAL可能是GDM患者针对体内血糖增高及胰岛素抵抗所产生的一种代偿效应,可以作为GDM早期预测因子或诊断生化指标。
[Abstract]:Objective to investigate the relationship between plasma glycidyl (gal) levels, glucose metabolism and insulin resistance in patients with gestational diabetes mellitus (GDM). Methods 40 patients with GDM and 40 patients with normal gestational glucose tolerance (NGT) were selected and their plasma GALs, fasting insulin, fasting blood glucose, blood glucose and insulin levels at 1h after taking glucose were measured, and insulin resistance and insulin sensitivity index (ISI) were calculated. Results the plasma gal level in GDM patients was significantly higher than that in NGT patients, and gal was positively correlated with body mass index, fasting blood glucose and postprandial blood glucose, and negatively correlated with insulin sensitivity index. Conclusion the expression of gal in plasma of patients with GDM was significantly increased, which was closely related to the changes of fasting blood glucose level, 1 hour postprandial blood glucose level, the decrease of insulin sensitivity and the change of body mass index during GDM. The overexpression of gal may be a compensatory effect of high blood glucose and insulin resistance in GDM patients. It can be used as an early predictor of GDM or a diagnostic biochemical index.
【作者单位】：扬州大学临床医学院内分泌科;扬州大学医学院中西医结合研究所;江苏省扬州市妇幼保健院妇产科;
【基金】：国家卫生和计划生育委员会科研基金(编号:W201309)
【分类号】：R714.256

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