SFlt-1、PLGF和sEng与子痫前期的相关性探讨

发布时间：2018-07-12 13:40

本文选题：子痫前期 + sFlt-　；参考：《齐齐哈尔医学院学报》2015年35期

【摘要】：目的研究sFlt-1、PLGF和sEng水平表达情况,以及它们与子痫前期的相关性;分析子痫前期与氧化应激、炎症机制的相关性。方法检测正常孕妇组、轻度子痫前期组、重度子痫前期组血样标本中的sFlt-1、PLGF、sEng及CRP的含量。结果重度PE患者的sFlt-1水平高于正常孕妇和轻度PE患者,而且差异均有统计学意义(q=10.64,8.10,P0.01);正常孕妇的PLGF水平高于轻度PE患者和重度PE患者,而且差异均有统计学意义(q=5.84,10.51,P0.01);正常孕妇的sEng水平低于轻度PE患者和重度PE患者,而且差异均有统计学意义(q=9.38,28.41,P0.01);正常孕妇的CRP水平低于轻度PE患者和重度PE患者,而且差异均有统计学意义(q=12.88,18.04,P0.01)。结论sFlt-1,PLGF,sEng可以用于子痫前期病的诊断,且可以反应病情进展,联合监测优于单一监测。
[Abstract]:Objective to study the expression of sFlt-1 PLGF and sEng and their correlation with preeclampsia, and to analyze the relationship between preeclampsia and oxidative stress and inflammatory mechanism. Methods the levels of serum sFlt-1 PLGFGF-sEng and CRP in normal pregnant women, mild preeclampsia and severe preeclampsia were detected. Results the levels of sFlt-1 in patients with severe PE were higher than those in normal women and mild patients with PE, and the differences were statistically significant (qP0.01), and the levels of PLGF in normal pregnant women were higher than those in patients with mild PE and those with severe PE (P 0.01). The levels of sEng in normal pregnant women were lower than those in mild PE patients and severe PE patients, and the differences were statistically significant (q9.38c28.41g P0.01), while the CRP levels of normal pregnant women were lower than those of mild PE patients and severe PE patients (P 0.01), and the levels of CRP in normal pregnant women were lower than those in mild PE patients and severe PE patients (P 0.01), and the levels of CRP in normal pregnant women were significantly lower than those in mild PE patients and severe PE patients. And the difference was statistically significant (QR 12.88, 18.04, P0.01). Conclusion sFlt-1 PLGFGF-sEng can be used in the diagnosis of preeclampsia and can reflect the progress of the disease, and the combined monitoring is better than the single monitoring.
【作者单位】：盐城市妇幼保健院;苏州大学附属第一人民医院;
【分类号】：R714.244

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