代谢重编程调控巨噬细胞极化及其在母-胎界面的作用
发布时间：2018-07-13 14:53
【摘要】：母-胎界面的免疫反应在妊娠建立、维持以及分娩发动中起至关重要的作用。正常的巨噬细胞极化及其功能是维持母-胎界面正常免疫微环境的基础,若异常,会导致子痫前期、早产等妊娠相关重大疾病的发生。代谢重编程是细胞对所处环境关键改变的反应统称,可以调控巨噬细胞的不同极化状态。本文对代谢重编程与巨噬细胞极化、母-胎界面巨噬细胞代谢以及代谢重编程对其极化类型的影响在正常妊娠和病理性妊娠中可能发挥的作用进行综述。
[Abstract]:The maternal-fetal interface immune response plays a crucial role in the establishment, maintenance and initiation of pregnancy. Normal macrophage polarization and its function are the basis of maintaining the normal immune microenvironment of maternal-fetal interface. If abnormal, it will lead to the occurrence of major pregnancy-related diseases such as preeclampsia and preterm delivery. Metabolic reprogramming is the response of cells to critical changes in their environment, which regulates the different polarization states of macrophages. In this paper, the effects of metabolic reprogramming and macrophage polarization, maternal / fetal interface macrophage metabolism and the effects of metabolic reprogramming on their polarization types in normal and pathological pregnancies were reviewed.
【作者单位】： 华中科技大学同济医学院计划生育研究所/生殖医学中心;
【基金】：国家自然科学基金面上项目(81671490) 华中科技大学同济医学院重大疾病研究交叉创新团队项目(5001519002)~~
【分类号】：R714
[Abstract]:The maternal-fetal interface immune response plays a crucial role in the establishment, maintenance and initiation of pregnancy. Normal macrophage polarization and its function are the basis of maintaining the normal immune microenvironment of maternal-fetal interface. If abnormal, it will lead to the occurrence of major pregnancy-related diseases such as preeclampsia and preterm delivery. Metabolic reprogramming is the response of cells to critical changes in their environment, which regulates the different polarization states of macrophages. In this paper, the effects of metabolic reprogramming and macrophage polarization, maternal / fetal interface macrophage metabolism and the effects of metabolic reprogramming on their polarization types in normal and pathological pregnancies were reviewed.
【作者单位】： 华中科技大学同济医学院计划生育研究所/生殖医学中心;
【基金】：国家自然科学基金面上项目(81671490) 华中科技大学同济医学院重大疾病研究交叉创新团队项目(5001519002)~~
【分类号】：R714
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