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卵巢恶性肿瘤的治疗与保留生殖功能的探讨

发布时间:2018-07-18 15:54
【摘要】:目的:探讨女性卵巢恶性肿瘤的临床特征、具体病理分型、手术实施方案、术后化疗方案以及生殖功能的保留对预后的影响。研究方法:对江苏省连云港市妇幼保健院2003-2013年10年间收治的患有卵巢恶性肿瘤的女性患者的病案进行回顾性的分析和总结。系统整理其临床特征、具体病理分型、疾病的临床分期、不同的手术方案、术后进行辅助化疗的差异、术后的生殖功能保留情况及预后,运用SPSS16.0软件进行统计分析,P0.05表示存在显著性差异。结果:10年间江苏省连云港市妇幼保健院共收治卵巢恶性肿瘤患者54例,最小年龄16岁,最大年龄67岁,,平均年龄31.2岁,中位年龄24.6岁。其中交界性上皮性肿瘤患者7例,卵巢上皮性恶性肿瘤患者15例,卵巢性索间质性肿瘤患者5例,生殖细胞性肿瘤患者20例,转移性肿瘤患者7例。患者无特异性临床表现,腹痛、腹胀、腹部包块是患者的通常表现,少数存在与月经相关的临床症状。患者多数为较早的临床分期, I期患者为26例,占48%;Ⅱ期患者6例,占11%;Ⅲ期患者13例,占24%;Ⅳ期患者9例,占16%。卵巢恶性肿瘤的预后情况和其临床分期直接相关,患者的预后情况的主要影响因素就是其临床分期。结论:生殖细胞肿瘤是卵巢恶性肿瘤最重要的一类。卵巢恶性肿瘤缺乏特异性的临床表现,而且早期筛查手段也不具备,因此对于女性妇科影像学检查也加以重视。患有卵巢恶性肿瘤的年纪较轻的女性患者,不管分期如何,其生育功能都可以保留,提高其生存质量。但是后期的随访非常必要。对于处于I期、 Ⅱ期的上皮性恶性肿瘤患者,患者有生育要求的,在长期严密随访的情况下,生育功能也可以保留。在本研究中,I期、 Ⅱ期上皮性恶性肿瘤患者中,不乏成功妊娠的案例,但是临床样本量还不够大。对于女性患者而言,一些能够尽量将卵巢以及生殖功能保留的保守治疗方案在临床上意义重大。卵巢恶性肿瘤在术后所进行的化疗会对卵巢功能产生一过性的影响。对于患有妇科恶性肿瘤的年轻女性,应该根据患者自身情况,制定个性化的治疗方案,不但要考虑到保守手术所存在的风险,还要考虑到根治手术所存在的缺陷,在两者之间找到平衡点。
[Abstract]:Objective: to investigate the effect of clinical features, pathological classification, operative regimen, postoperative chemotherapy and reproductive function retention on the prognosis of female ovarian malignant tumors. Methods: the medical records of female patients with ovarian malignant tumor admitted from 2003 to 2013 in Lianyungang MCH Hospital of Jiangsu Province were retrospectively analyzed and summarized. The clinical features, specific pathological types, clinical stages of the disease, different surgical schemes, differences in postoperative adjuvant chemotherapy, preservation of reproductive function and prognosis were systematically sorted out. SPSS 16.0 software was used for statistical analysis. Results during the past 10 years, 54 patients with malignant ovarian tumors were treated in Lianyungang MCH Hospital of Jiangsu Province. The youngest age was 16 years, the maximum age was 67 years, the average age was 31.2 years, and the median age was 24.6 years. Among them, there were 7 cases of borderline epithelial tumor, 15 cases of ovarian epithelial malignant tumor, 5 cases of ovarian cord stromal tumor, 20 cases of germ cell tumor and 7 cases of metastatic tumor. No specific clinical manifestations, abdominal pain, abdominal distension, abdominal mass is the usual manifestation of patients, a few clinical symptoms associated with menstruation. The majority of the patients were early clinical staging, with 26 patients in stage I (48 patients), 6 patients in stage II (1111patients), 13 patients in stage 鈪

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