血清肿瘤标志物联合检测在卵巢癌早期诊断中的临床价值研究

发布时间：2018-07-20 09:08

【摘要】：目的探讨联合检测溶血磷脂酸(LPA)、恶性肿瘤特异性生长因子(TSGF)、糖类抗原125(CA125)在早期卵巢癌早期诊断中的价值和意义。方法按照随机数字表的方法选取124例于2014年2月至2016年1月间就诊的卵巢癌患者作为研究对象并设为卵巢癌组,同样按照随机数字表的方法选取于2014年2月至2016年1月间来我院就诊的42例卵巢良性肿瘤以及50例健康体检女性患者作为研究对象并分别设为卵巢良性肿瘤组和正常对照组,分别检测三组患者的血清LPA、TSGF和CA125,进行统计学分析并判断联合检测三种血清肿瘤标志物在临床应用价值。结果卵巢癌组患者血清LPA、TSGF、CA125水平明显高于卵巢良性肿瘤组和正常对照组,卵巢良性肿瘤组血清LPA、TSGF、CA125水平明显高于正常对照组,差异均有统计学意义(P0.05)。LPA、TSGF、CA125联合检测其灵敏度、特异度较单一检测、两两检测相比均显著升高。结论卵巢癌早期患者在诊疗过程中联合检测LPA、TSGF、CA125三者水平,能够提高临床检测的灵敏度和特异度,有助于临床早期发现病情并实施有效的治疗手段。
[Abstract]:Objective to investigate the value and significance of combined detection of lysophosphatidic acid (LPA), tumor specific growth factor (TSGF) and carbohydrate antigen 125 (CA125) in early diagnosis of ovarian cancer. Methods 124 patients with ovarian cancer from February 2014 to January 2016 were selected as the study subjects and selected as ovarian cancer group. According to the method of random number table, 42 patients with benign ovarian tumor and 50 healthy women who were treated in our hospital from February 2014 to January 2016 were selected as the study subjects and divided into benign ovarian tumor group and normal control group, respectively. The serum LPA-TSGF and CA125 of the three groups were detected, and the clinical value of combined detection of three serum tumor markers was evaluated. Results the serum levels of LPA-TGFGFCA125 in ovarian cancer group were significantly higher than those in benign ovarian tumor group and normal control group, and the serum LPA-TSGFGFCA125 level in ovarian benign tumor group was significantly higher than that in normal control group. The difference was statistically significant (P0.05). The specificity was significantly higher than that of single detection and pairwise detection. Conclusion the combined detection of LPA-TSGFCA125 in the early stage of ovarian cancer can improve the sensitivity and specificity of clinical detection and is helpful to the early detection of the disease and the effective treatment.
【作者单位】：新疆医科大学附属肿瘤医院妇科;
【基金】：新疆自治区科学技术厅自然科学基金项目(编号:2012211A044)
【分类号】：R737.31

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