复方沙棘籽油栓治疗宫颈HPV感染的疗效分析

发布时间：2018-07-20 10:32

【摘要】：目的：探讨复方沙棘籽油栓治疗宫颈感染HPV的疗效、HPV载量对药物治疗结局的影响，为临床医生对高危型HPV感染人群的治疗提供指导。方法：试验抽取了2012年12月至2013年12月吉林大学第一医院肿瘤妇科门诊中宫颈感染高危型HPV的患者169例，随机分为治疗组（91例）与对照组（78例），治疗组给予复方沙棘籽油栓阴道上药3个月，对照组不使用药物治疗，两组均于3个月后行TCT及HPV检查，试验期间均禁止性生活及使用其他药物。结果： 1.复方沙棘籽油栓药物治疗高危型HPV感染3个月复查后，治疗组总有效率为74.73%（68/91），而对照组总有效率62.82%（49/78），治疗组总有效率高于对照组，差异有统计学意义（p0.05）。 2.治疗组91例患者年龄21-59岁，平均（39.57±8.54）岁，对照组61例患者年龄21-60岁，平均（40.01±9.93）岁，（p0.05），治疗组和对照组年龄分布具有均衡性。 3.治疗组中低载量组中27人治愈，16人有效，总有效率为87.75%（43/49），中载量组中11人治愈，7人有效，总有效率69.23%（18/26），高载量组中5人治愈，2人有效，，总有效率为43.75%（7/16），治疗效果低载量组中载量组高载量组，差异有统计学意义（p 0.05）。结论： 1.复方沙棘籽油栓治疗宫颈高危型HPV感染是有效的，其疗效呈随着宿主病毒载量的上升而下降的趋势，针对HPV治疗的过程中不能单独以HPV载量下降作为治愈或好转的标准，需要结合TCT或阴道镜结果对疾病的转归做综合评估。 2.若患者高危型HPV为阳性，不论其病毒载量的高低，均应尽早进行临床干预。
[Abstract]:Objective: to investigate the effect of compound Hippophae rhamnoides seed oil suppository on the outcome of drug therapy for cervical HPV infection. Methods: from December 2012 to December 2013, 169 patients with high-risk HPV of cervical infection were selected from the Department of Oncology and Gynecology, first Hospital of Jilin University. They were randomly divided into treatment group (n = 91) and control group (n = 78). The treatment group was treated with compound seabuckthorn seed oil suppository for 3 months, while the control group was not treated with drugs. TCT and HPV were performed in both groups after 3 months. Sexual life and use of other drugs are prohibited during the trial. Results: 1. The total effective rate of the treatment group was 74.73% (68 / 91), while the total effective rate of the control group was 62.82% (49 / 78). The total effective rate of the treatment group was higher than that of the control group (p0.05). The age of 91 patients in the treatment group was 21-59 years old (mean (39.57 卤8.54) years), and that in the control group was 21-60 years old (mean (40.01 卤9.93) years, p0.05). The total effective rate was 87.75% (43 / 49) in the treatment group, 7 cases in the middle load group, 69.23% (18 / 26) in the middle load group, and 2 cases in 5 cases in the high load group. The total effective rate was 87.75% (43 / 49) in 27 patients in the treatment group, and 69.23% (18 / 26) in the middle load group, the total effective rate was 87.75% (43 / 49). The total effective rate was 43.75% (7 / 16). Conclusion: 1. Compound Hippophae rhamnoides seed oil suppository is effective in the treatment of high-risk HPV infection in cervix, and its curative effect tends to decrease with the increase of host virus load. Combined with TCT or colposcopy results, the outcome of the disease needs to be evaluated synthetically. 2. If high-risk HPV is positive, clinical intervention should be carried out as soon as possible, regardless of viral load.
【学位授予单位】：吉林大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R737.33

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