缩宫素受体在子宫内膜异位症子宫结合带中表达的研究
发布时间：2018-07-21 13:50
【摘要】：目的:探讨在不同月经周期子宫内膜异位症颈体结合及宫底部子宫结合带中OTR的表达水平研究。方法:收取因子宫内膜异位症行子宫切除术的颈体结合及宫底部子宫结合带蜡块组织21例为观察组,其中增生期16例,分泌期5例。收集同期因宫颈癌、卵巢癌或宫颈上皮内瘤变III行子宫切除术的患者子宫结合带蜡块组织48例为对照组,其中增生期26例,分泌期22例。采用免疫组织化学方法检测各组子宫结合带组织中OTR的表达水平。结果:OTR表达在实验组和对照组JZ平滑肌细胞质中。在正常的子宫中,增生期颈体部位子宫结合带OTR表达高于宫底部位(p0.05),分泌期颈体部位子宫结合带OTR表达低于宫底部位(p0.05)。无论是颈体部位还是宫底部位,增生期OTR的表达高于分泌期(p0.05)。无论是增生期还是分泌期,EMT颈体部位OTR的水平与宫底部OTR无统计学差异(p0.05)。无论在颈体还是宫底部位,EMT增生期与分泌期OTR水平无统计学差异(p0.05)。r ASRM I期和II期宫底部位子宫结合带缩宫素受体表达低于r ASRM III期和IV期(p0.05)。卵巢型子宫内膜异位症宫底部位子宫结合带OTR的表达低于深部结节型子宫内膜异位症宫底部子宫结合带OTR的水平(p0.05)。宫底部OTR的表达水平与痛经的程度成正相关(r=0.872,p0.05)。与正常子宫相比,分泌期颈体与宫底OTR水平表达升高(p0.05)。无论是增生期还是分泌期,EMT宫底部位子宫结合带OTR的水平表达均高于正常子宫(p0.05)。结论:子宫内膜异位症子宫结合OTR有异常表达现象,可能会导致子宫的异常收缩,引起痛经和生育力的下降。
[Abstract]:Aim: to investigate the expression of OTR in cervical body binding and uterine binding zone of endometriosis in different menstrual cycles. Methods: a total of 21 cases of cervical-body binding and uterine binding with waxed tissue were collected from 21 cases of endometriosis treated by hysterectomy, including 16 cases in proliferative phase and 5 cases in secretory phase. A total of 48 cases of uterine binding waxy tissue were collected as the control group, including 26 cases in proliferative phase and 22 cases in secretory phase, who underwent hysterectomy due to cervical cancer, ovarian cancer or cervical intraepithelial neoplasia III. The expression of OTR in uterine binding zone was detected by immunohistochemical method. Results OTR was expressed in the JZ smooth muscle cytoplasm of the experimental group and the control group. In normal uterus, the expression of OTR in uterine binding zone in proliferative cervical body was higher than that in subuterine floor (p0.05), and the expression of OTR in uterine binding zone in secretory cervical body was lower than that in subuterine floor (p0.05). The expression of OTR in proliferative phase was higher than that in secretory phase (p0.05). There was no significant difference between the level of OTR in the cervical body of EMT and the OTR in the fundus of the uterus in proliferative or secretory phase (p0.05). There was no significant difference in the level of OTR between proliferative and secretory phases of EMT in the cervical body and the fundus of uterus (p0.05). The expression of oxytocin receptor in uterine binding zone in stage I and II was lower than that in stage III and IV (p0.05). The expression of OTR in uterine binding zone of ovarian endometriosis was lower than that in deep nodular endometriosis (p0.05). The expression of OTR in the fundus of uterus was positively correlated with the degree of dysmenorrhea (r 0.872p0.05). Compared with normal uterus, the expression of OTR in cervical and fundus during secretory phase was higher than that in normal uterus (p0.05). The expression of OTR in uterine binding zone of EMT was higher than that in normal uterus (p0.05). Conclusion: the abnormal expression of OTR in endometriosis may lead to abnormal contraction of uterus and decrease of dysmenorrhea and fertility.
【学位授予单位】：安徽医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R711.71
本文编号：2135730
[Abstract]:Aim: to investigate the expression of OTR in cervical body binding and uterine binding zone of endometriosis in different menstrual cycles. Methods: a total of 21 cases of cervical-body binding and uterine binding with waxed tissue were collected from 21 cases of endometriosis treated by hysterectomy, including 16 cases in proliferative phase and 5 cases in secretory phase. A total of 48 cases of uterine binding waxy tissue were collected as the control group, including 26 cases in proliferative phase and 22 cases in secretory phase, who underwent hysterectomy due to cervical cancer, ovarian cancer or cervical intraepithelial neoplasia III. The expression of OTR in uterine binding zone was detected by immunohistochemical method. Results OTR was expressed in the JZ smooth muscle cytoplasm of the experimental group and the control group. In normal uterus, the expression of OTR in uterine binding zone in proliferative cervical body was higher than that in subuterine floor (p0.05), and the expression of OTR in uterine binding zone in secretory cervical body was lower than that in subuterine floor (p0.05). The expression of OTR in proliferative phase was higher than that in secretory phase (p0.05). There was no significant difference between the level of OTR in the cervical body of EMT and the OTR in the fundus of the uterus in proliferative or secretory phase (p0.05). There was no significant difference in the level of OTR between proliferative and secretory phases of EMT in the cervical body and the fundus of uterus (p0.05). The expression of oxytocin receptor in uterine binding zone in stage I and II was lower than that in stage III and IV (p0.05). The expression of OTR in uterine binding zone of ovarian endometriosis was lower than that in deep nodular endometriosis (p0.05). The expression of OTR in the fundus of uterus was positively correlated with the degree of dysmenorrhea (r 0.872p0.05). Compared with normal uterus, the expression of OTR in cervical and fundus during secretory phase was higher than that in normal uterus (p0.05). The expression of OTR in uterine binding zone of EMT was higher than that in normal uterus (p0.05). Conclusion: the abnormal expression of OTR in endometriosis may lead to abnormal contraction of uterus and decrease of dysmenorrhea and fertility.
【学位授予单位】：安徽医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R711.71
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