囊胚和卵裂期胚胎玻璃化冷冻解冻移植周期的妊娠结果分析

发布时间：2018-07-22 12:48

【摘要】：目的:比较囊胚和卵裂期胚胎玻璃化冷冻解冻后移植周期的妊娠结果。方法:回顾分析2014年1月至2014年12月在我院生殖医学中心行玻璃化冷冻解冻移植周期388个患者的妊娠情况,其中囊胚冷冻解冻165个移植周期(A组),卵裂期胚胎冷冻解冻223个移植周期(B组)。结果:A组和B组解冻存活率分别98.76%和96.74%,两组间无统计学差异(P0.05);临床妊娠率、种植率和单胎率A组(68.48%、57.38%和76.10%)显著高于B组(68.48%、57.38%和59.37%);多胎率、双胎率和三胎率A组(23.01%、22.12%和0.88%)显著低于B组(40.62%、31.25%和9.37%,P0.05);A组和B组的流产率分别为5.31%和6.25%,两组间无统计学差异。结论:囊胚和卵裂期胚胎玻璃化冷冻解冻均能获得较高的存活率、临床妊娠率和种植率,且囊胚玻璃化冷冻移植周期提高了临床妊娠率及种植率,同时降低了多胎率的发生。
[Abstract]:Objective: to compare the pregnancy results between blastocysts and cleavage embryos after vitrification and thawing. Methods: from January 2014 to December 2014, the pregnancy of 388 patients with vitrification and thawing transplantation in our reproductive medicine center was analyzed retrospectively. The blastocysts were frozen and thawed for 165 transfer cycles (group A) and 223 cycles (group B) for cryopreservation and thawing of blastocysts. Results the thawing survival rates of group A and group B were 98.76% and 96.74%, respectively. There was no significant difference between the two groups (P0.05), the clinical pregnancy rate, implantation rate and single pregnancy rate in group A (68.48% and 76.10%) were significantly higher than those in group B (68.48% and 57.37%), and the rate of multiple pregnancy was higher than that in group B (57.38% and 59.37%). The abortion rates of group A and group B were 5.31% and 6.25%, respectively, which were significantly lower than those of group B (40.62%, 31.25% and 9.37%, P 0.05), with no significant difference between the two groups, and the rate of abortion in group A (23.01%) and group B (0.88%) was significantly lower than that in group B (4.62% and 9.37%, P 0.05), and the abortion rates of group A and group B were 5.31% and 6.25%, respectively. Conclusion: vitrification and thawing of blastocysts and cleavage embryos can obtain high survival rate, clinical pregnancy rate and implantation rate, and vitrified blastocyst cryopreservation transfer cycle can increase the clinical pregnancy rate and implantation rate, and reduce the occurrence of multiple embryos.
【作者单位】：湖北医药学院附属人民医院生殖医学研究中心;
【分类号】：R714.8

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