妊娠及产褥期妇女并发下肢深静脉血栓溶栓治疗的临床疗效观察

发布时间：2018-07-23 15:46

【摘要】：目的探讨妊娠及产褥期妇女并发下肢深静脉血栓溶栓治疗的临床疗效。方法选择2012年3月至2015年7月在河南省郑州市第十五人民医院妇产科住院治疗的69例妊娠及产褥期并发下肢深静脉血栓患者作为研究对象,均给予尿激酶静脉溶栓治疗以及肝素抗凝治疗,比较其治疗前及治疗后3、7 d的各项凝血功能指标、患肢肿胀程度和各项下肢阻抗容积波图指标变化情况。结果治疗前及治疗后3、7 d患者的Fi B呈显著下降趋势,而PT、APTT均呈显著升高趋势(均P0.001);治疗后3、7 d患者的股骨中段周径、胫骨中段周径均显著减小(均P0.001);与健侧相比,患者患肢肿胀程度明显改善(P0.05);治疗前及治疗后3、7 d患者的IPG升高值、IPG下降值、IPG下降值/IPG升高值、阻抗变化比率均呈显著升高趋势(均P0.001)。结论溶栓治疗快速溶解下肢血栓、改善其静脉回流,对于妊娠及产褥期并发下肢深静脉血栓患者具有较为明显的临床疗效。
[Abstract]:Objective to investigate the clinical effect of thrombolytic therapy for lower extremity deep vein thrombosis in pregnant and puerperium women. Methods 69 cases of pregnancy and puerperium complicated with deep venous thrombosis of lower extremity were selected from March 2012 to July 2015 in the 15th people's Hospital of Zhengzhou, Henan Province. All patients were treated with urokinase intravenous thrombolytic therapy and heparin anticoagulant therapy. The indexes of coagulation function, swelling degree of affected limb and impedance volume wave of lower extremity were compared before and after 3 to 7 days of treatment. Results the FI-B of patients before and after treatment decreased significantly, but PTT APTT increased significantly (all P0.001), and the diameter of femur and middle tibia decreased significantly (P0.001), compared with healthy side, the diameter of midfemur and middle tibia decreased significantly (P0.001). The swelling degree of the affected limbs was significantly improved (P0.05), and the IPG decreased value and the ratio of impedance change were significantly increased before treatment and 3 days after treatment (all P0.001). Conclusion Thrombolytic therapy for rapid dissolution of lower extremity thrombus and improvement of venous reflux is effective in pregnancy and puerperium complicated with deep venous thrombosis of lower extremity.
【作者单位】：河南省郑州市第十五人民医院妇产科;
【分类号】：R714

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