中性粒细胞与淋巴细胞比值与子痫前期的关系

发布时间：2018-07-24 16:17

【摘要】：目的:分析中性粒细胞与淋巴细胞比值(neutrophil to lymphocyte ratio,NLR)与子痫前期的关系,探讨NLR预测子痫前期的临床意义。方法:选取2014年1月1日至2015年12月31日在延边大学附属医院产科分娩的209例孕妇分为对照组(正常妊娠孕妇105例)、轻度子痫前期组(MPE组)53例、重度子痫前期组(SPE组)51例,检测各组患者的血常规指标,计算NLR值,比较对照组和子痫前期组NLR的关系。结果:1.MPE、SPE组孕妇的年龄均大于正常妊娠组,且随着疾病严重程度增加呈上升趋势;MPE、SPE组孕妇的分娩孕龄、新生儿出生体重均小于正常妊娠组,且随着疾病严重程度增加均呈下降趋势(均P0.001);2.NLR与孕妇的年龄呈正相关,与分娩孕龄和新生儿出生体重呈负相关;3.调整孕妇年龄、分娩孕龄及新生儿出生体重后,MPE、SPE组的中性粒细胞计数、NLR水平均高于正常妊娠组(均P0.001),且随着疾病严重程度增加呈上升趋势;三组间淋巴细胞计数差异无统计学意义(P=0.204);4.随着中性粒细胞计数、NLR水平的升高,子痫前期的患病率也上升。结论:1.随着NLR水平升高,子痫前期的患病率也上升;2.子痫前期组NLR水平高于正常妊娠组,NLR可作为预测子痫前期的常用参考指标,且与疾病的严重程度有明显相关性。
[Abstract]:Objective: to analyze the relationship between neutrophil to lymphocyte ratio (NLR) and preeclampsia, and to explore the clinical significance of NLR to predict preeclampsia. Methods: 209 pregnant women who delivered in the obstetric department of the Affiliated Hospital of Yanbian University from January 1, 2014 to December 31, 2015 were divided into control group (105 cases of normal pregnant women), 53 cases of mild preeclampsia group (group MPE) and 51 cases of severe preeclampsia group (group SPE), the blood routine indexes of each group were measured, the NLR value was calculated, and the relationship between the control group and the pre eclampsia group NLR was compared. Results: 1.MPE, SPE group were older than the normal pregnancy group, and increased with the increase of the severity of the disease; MPE, SPE group pregnant women's delivery. The birth weight of the newborn was less than that of the normal pregnancy group and decreased with the increase of the severity of the disease (all P0.001). 2.NLR was positively correlated with the age of pregnant women, and was negatively correlated with the birth weight and birth weight of the newborn. 3. the neutrophils count in the group of MPE and SPE was adjusted after the pregnant women's age, birth gestational age and birth weight. The NLR level was higher than that of the normal pregnancy group (P0.001), and increased with the increase of the severity of the disease; there was no statistical difference between the three groups (P=0.204); 4. with the neutrophils count, the increase of the level of NLR and the prevalence of preeclampsia. Conclusion: 1. with the increase of NLR level, the prevalence rate of preeclampsia is also The NLR level in the 2. preeclampsia group was higher than that in the normal pregnancy group. NLR could be used as a common reference index to predict preeclampsia, and had a significant correlation with the severity of the disease.
【学位授予单位】：延边大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R714.244

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