高危型HPV阳性细胞学阴性维吾尔族妇女的分流管理
发布时间：2018-07-24 21:46
【摘要】：目的统计≥30岁维吾尔族妇女不同型别人乳头瘤病毒(human papillomavivus,HPV)感染和宫颈细胞学检查结果,分析不同型别HPV感染发生高度宫颈病变(≥CIN2)的风险,为规范化管理未发生宫颈病变和HPV阳性的妇女提供理论依据。方法收集2012-01-01-2014-02-28新疆维吾尔自治区人民医院妇产科不同型别HPV感染且宫颈细胞学检查未见异常的维吾尔族妇女199例,根据不同HPV型别进行分组,常规全部行阴道镜检查,行宫颈多点活检组织病理学检查,根据病检结果分析各个型别宫颈高度病变的患病率,运用Logistic回归分析不同型别HPV妇女发生高度宫颈病变的风险。结果 199例宫颈细胞学检查未见异常,但HPV分型检测15种高危型HPV阳性的维吾尔族妇女中感染位居前5位的为HPV16、58、52、53和31型。其中高度宫颈病变的患病率为18.59%(37/199),HPV阳性的各个型别中诊断≥CIN2级病变有HPV 16、58、52、31和18型,HPV16型阳性患者发生≥CIN2级病变的患病率为38.48%(20/58),HPV58型阳性的患病率为30.23%(13/43),HPV52型的患病率为5.90%(2/34),HPV31型阳性的患病率为3.70%(1/27),HPV18型阳性的患病率为11.11%(1/9)。HPV16型感染发生≥CIN2级的危险是无HPV16型感染者的3.839倍,95%CI为1.829~8.060,P0.001;HPV58型感染发生≥CIN2级的危险是无HPV58型感染者的2.365倍,95%CI为1.476~7.669,P=0.004。结论对于≥30岁维吾尔族妇女宫颈细胞学检查未见异常但高危型HPV阳性者尤其是HPV16和58型阳性者,发生宫颈高度病变的风险较高,应行阴道镜检查,必要时做活检。
[Abstract]:Objective to analyze the risk of human papillomavirus (CIN2) infection and cervical cytology in Uygur women aged more than 30 years. To provide theoretical basis for standardized management of women without cervical lesions and HPV positive. Methods 199 Uygur women with different types of HPV infection in gynaecology and obstetrics department in Xinjiang Uygur Autonomous region people's Hospital were collected from 2012-01-01-2014-02-28. According to different types of HPV, 199 women of Uygur nationality were divided into groups according to different types of HPV, and all of them were examined with colposcopy. Histopathological examination of cervical multipoint biopsy was performed to analyze the prevalence rate of high cervical lesions in different types of HPV according to the results of pathological examination. Logistic regression analysis was used to analyze the risk of high cervical lesions in women with different types of HPV. Results there was no abnormality in cervical cytology in 199 cases, but among the 15 high risk HPV positive Uygur women detected by HPV typing, the top 5 were HPV161658-52C53 and 31. The prevalence rate of high cervical lesions was 18.59% (37 / 199) in all types of HPV-positive lesions 鈮，
本文编号：2142751
[Abstract]:Objective to analyze the risk of human papillomavirus (CIN2) infection and cervical cytology in Uygur women aged more than 30 years. To provide theoretical basis for standardized management of women without cervical lesions and HPV positive. Methods 199 Uygur women with different types of HPV infection in gynaecology and obstetrics department in Xinjiang Uygur Autonomous region people's Hospital were collected from 2012-01-01-2014-02-28. According to different types of HPV, 199 women of Uygur nationality were divided into groups according to different types of HPV, and all of them were examined with colposcopy. Histopathological examination of cervical multipoint biopsy was performed to analyze the prevalence rate of high cervical lesions in different types of HPV according to the results of pathological examination. Logistic regression analysis was used to analyze the risk of high cervical lesions in women with different types of HPV. Results there was no abnormality in cervical cytology in 199 cases, but among the 15 high risk HPV positive Uygur women detected by HPV typing, the top 5 were HPV161658-52C53 and 31. The prevalence rate of high cervical lesions was 18.59% (37 / 199) in all types of HPV-positive lesions 鈮，
本文编号：2142751
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