除湿止带方联合干扰素治疗湿热下注型宫颈高危型HPV感染的临床研究
发布时间：2018-07-25 08:48
【摘要】：目的：通过观察除湿止带方联合干扰素治疗湿热下注型宫颈高危型人乳头瘤病毒(high risk human papilloma viruses, HR-HPV)感染的临床疗效,寻求有效的中药组方治疗宫颈HR-HPV感染,有效防治宫颈癌的发生。方法：采用随机对照研究方法,纳入符合湿热下注型HR-HPV感染的病例80例,并随机分为治疗组和对照组,治疗组病例40例,对照组病例40例。治疗组选除湿止带方联合干扰素阴道上药治疗,对照组采用干扰素阴道上药,于月经干净后3天开始治疗,每周期连续治疗14天,共治疗三个月经周期。观察比较两组的证候积分变化、HR-HPV转阴情况、白带清洁度以及安全性指标,并进行统计学分析,比较不同治疗方法的临床疗效。结果：1.研究显示两组患者治疗后各证候积分及总积分与治疗前比较,差异有统计学意义,两种治疗方案均能改善各证候。2.治疗组和对照组的中医临床证候疗效有统计学差异(Z=-3.841,P=0.000),提示治疗组在改善患者临床证候方面,疗效明显优于对照组。3.治疗组HPV转阴率为55.0%,对照组转阴率为32.5%,χ2=4.114,P=0.043,差异有统计学意义,提示治疗组对HR-HPV感染转阴效果优于对照组。4.对比HPV33、HPV52、HPV58及其它9项高危型HPV四种常见病理分型的转阴情况,经分层卡方检验,结果显示治疗组和对照组治疗不同病理分型的宫颈HR-HPV感染的疗效相当。5.对比两组治疗后白带清洁度情况,结果无统计学差异(Z=-0.325,P=0.745),说明在改善白带清洁度方面,两组疗效相当。6.治疗过程中,所有受试者均未出现不良事件,且安全性指标均未见明显异常变化。结论：1.对湿热下注型宫颈HR-HPV感染的患者采用除湿止带方联合干扰素治疗,能显著改善患者临床证候,提高宫颈HR-HPV感染转阴率。2.除湿止带方联合干扰素治疗宫颈HR-HPV感染,疗效优于单纯运用干扰素。
[Abstract]:Objective: to observe the clinical curative effect of dehumidification Zhizhuangfang combined with interferon in the treatment of high risk human papillomavirus (high risk human papilloma viruses, HR-HPV) infection of cervix with dampness and heat, and to seek an effective prescription for the treatment of cervical HR-HPV infection and the prevention and treatment of cervical cancer. Methods: a randomized controlled study was conducted in 80 patients with HR-HPV infection according to damp-heat betting type, and were randomly divided into two groups: treatment group (n = 40) and control group (n = 40). In the treatment group, the treatment group was treated with the prescription of removing dampness and Zhibanfang combined with interferon vagina, while the control group was treated with interferon vagina. The treatment began on 3 days after menstruation was clean, and was treated continuously for 14 days in each cycle for three menstrual cycles. To observe and compare the changes of syndromes integral changes of HR-HPV, leucorrhea cleanliness and safety index, and to compare the clinical efficacy of different treatment methods. The result is 1: 1. The study shows that the difference between the two groups after treatment and before treatment is statistically significant, the two treatment schemes can improve the symptoms of each syndrome. 2. The curative effect of TCM syndromes in treatment group and control group was statistically different (ZHI-3.841PU 0.000), which indicated that the therapeutic effect of treatment group was obviously better than that of control group in improving the clinical syndrome of patients. The negative conversion rate of HPV in the treatment group was 55.0 and that in the control group was 32.5. The difference was statistically significant. It suggested that the negative conversion of HR-HPV infection in the treatment group was better than that in the control group. The four common pathological types of HPV33, HPV52, HPV58 and 9 other high-risk types of HPV were compared. The results of stratified chi-square test showed that the therapeutic effect of treatment group and control group on cervical HR-HPV infection of different pathological types was equal to that of control group. There was no statistical difference between the two groups in the cleanliness of leucorrhoea after treatment (ZC- 0.325 P0. 745), which indicated that the effect of the two groups in improving the leucorrhea cleanliness was equivalent to. 6. 6. In the course of treatment, no adverse events were found in all subjects, and no obvious abnormal changes in safety indices were observed. Conclusion 1. The treatment of dampness and heat betting type of cervix HR-HPV infection with dehumidification and zhizongfang combined with interferon can significantly improve the clinical symptoms of the patients and increase the negative rate of cervical HR-HPV infection. 2. The therapeutic effect of dehumidification and interferon on cervical HR-HPV infection is better than that of interferon alone.
【学位授予单位】：福建中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R737.33
本文编号：2143277
[Abstract]:Objective: to observe the clinical curative effect of dehumidification Zhizhuangfang combined with interferon in the treatment of high risk human papillomavirus (high risk human papilloma viruses, HR-HPV) infection of cervix with dampness and heat, and to seek an effective prescription for the treatment of cervical HR-HPV infection and the prevention and treatment of cervical cancer. Methods: a randomized controlled study was conducted in 80 patients with HR-HPV infection according to damp-heat betting type, and were randomly divided into two groups: treatment group (n = 40) and control group (n = 40). In the treatment group, the treatment group was treated with the prescription of removing dampness and Zhibanfang combined with interferon vagina, while the control group was treated with interferon vagina. The treatment began on 3 days after menstruation was clean, and was treated continuously for 14 days in each cycle for three menstrual cycles. To observe and compare the changes of syndromes integral changes of HR-HPV, leucorrhea cleanliness and safety index, and to compare the clinical efficacy of different treatment methods. The result is 1: 1. The study shows that the difference between the two groups after treatment and before treatment is statistically significant, the two treatment schemes can improve the symptoms of each syndrome. 2. The curative effect of TCM syndromes in treatment group and control group was statistically different (ZHI-3.841PU 0.000), which indicated that the therapeutic effect of treatment group was obviously better than that of control group in improving the clinical syndrome of patients. The negative conversion rate of HPV in the treatment group was 55.0 and that in the control group was 32.5. The difference was statistically significant. It suggested that the negative conversion of HR-HPV infection in the treatment group was better than that in the control group. The four common pathological types of HPV33, HPV52, HPV58 and 9 other high-risk types of HPV were compared. The results of stratified chi-square test showed that the therapeutic effect of treatment group and control group on cervical HR-HPV infection of different pathological types was equal to that of control group. There was no statistical difference between the two groups in the cleanliness of leucorrhoea after treatment (ZC- 0.325 P0. 745), which indicated that the effect of the two groups in improving the leucorrhea cleanliness was equivalent to. 6. 6. In the course of treatment, no adverse events were found in all subjects, and no obvious abnormal changes in safety indices were observed. Conclusion 1. The treatment of dampness and heat betting type of cervix HR-HPV infection with dehumidification and zhizongfang combined with interferon can significantly improve the clinical symptoms of the patients and increase the negative rate of cervical HR-HPV infection. 2. The therapeutic effect of dehumidification and interferon on cervical HR-HPV infection is better than that of interferon alone.
【学位授予单位】：福建中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R737.33
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