卵巢转移性黏液性肿瘤27例临床病理分析
发布时间：2018-07-26 14:26
【摘要】：目的探讨卵巢转移性黏液性肿瘤(metastatic mucinous neoplasms,MMN)的临床病理学特征。方法对27例卵巢MMN标本行HE、免疫组化SP法染色及临床病理资料分析。结果 27例卵巢MMN肿瘤直径2~28 cm,平均12.5 cm;发生于双侧者12例,单侧者15例(右侧13例);来源于阑尾19例、结肠5例、子宫颈2例、胰腺1例;大体呈囊性或囊实性者16例,实性11例;光镜下来源于阑尾及胰腺者可见类似良性的囊腺瘤样区域,实性区域可见毁损性的间质浸润,来源于结肠及子宫颈者可见弥漫性间质浸润及黏液渗出;免疫组化标记CK20多数阳性,CK7少数阳性,MUC-2的阳性率高于MUC-1,CDX-2及villin绝大多数阳性。结论卵巢MMN的诊断需紧密联系临床,免疫组化标记仅有一定的辅助作用。
[Abstract]:Objective to investigate the clinicopathological features of ovarian metastatic mucinous tumor (metastatic mucinous neoplasm). Methods 27 cases of ovarian MMN were studied by immunohistochemistry SP staining and clinicopathological data. Results 27 cases of ovarian MMN tumors were 28 cm in diameter (mean 12.5 cm), bilateral in 12 cases, unilateral in 15 cases (right 13 cases), originated from appendix in 19 cases, colon in 5 cases, cervix in 2 cases, pancreas in 1 case, cystic or cystic in 16 cases. 11 cases were solid. Diffuse interstitial infiltration and mucus exudation could be seen in the solid area and colon and cervix in 11 cases which were similar to benign cystadenomatous area under the light microscope, and diffuse interstitial infiltration and mucus exudation could be seen in the solid area from the colon and cervix. Immunohistochemical staining showed that the majority of CK20 positive and a few of Muc-2 positive were higher than those of MUC-1, CDX-2 and villin. Conclusion the diagnosis of ovarian MMN should be closely related to clinic.
【作者单位】： 安徽医科大学基础医学院病理学教研室;安徽省立医院病理科;
【基金】：安徽省卫生厅医学科研课题(13zc037)
【分类号】：R737.31
[Abstract]:Objective to investigate the clinicopathological features of ovarian metastatic mucinous tumor (metastatic mucinous neoplasm). Methods 27 cases of ovarian MMN were studied by immunohistochemistry SP staining and clinicopathological data. Results 27 cases of ovarian MMN tumors were 28 cm in diameter (mean 12.5 cm), bilateral in 12 cases, unilateral in 15 cases (right 13 cases), originated from appendix in 19 cases, colon in 5 cases, cervix in 2 cases, pancreas in 1 case, cystic or cystic in 16 cases. 11 cases were solid. Diffuse interstitial infiltration and mucus exudation could be seen in the solid area and colon and cervix in 11 cases which were similar to benign cystadenomatous area under the light microscope, and diffuse interstitial infiltration and mucus exudation could be seen in the solid area from the colon and cervix. Immunohistochemical staining showed that the majority of CK20 positive and a few of Muc-2 positive were higher than those of MUC-1, CDX-2 and villin. Conclusion the diagnosis of ovarian MMN should be closely related to clinic.
【作者单位】： 安徽医科大学基础医学院病理学教研室;安徽省立医院病理科;
【基金】：安徽省卫生厅医学科研课题(13zc037)
【分类号】：R737.31
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