HMG诱导排卵疗效相关证型分布规律研究

发布时间：2018-07-27 09:18

【摘要】：目的:探讨HMG诱导排卵疗效相关证型分布规律及尺肤诊的临床诊断价值,为各种临床表症的排卵障碍性不孕症患者是否应采取HMG促排治疗及促排失败后如何选择最佳的中医后续治疗方案提供证候学依据和辨证思路。方法:采集接受尿促性素(HMG)诱导排卵治疗成功病例(70例)和失败病例(180例)的症状、舌象、脉象等四诊信息,进行Logistic回归分析、因子分析、聚类分析等统计学处理。结果:1.两组间诸多四诊信息差异有统计学意义。多元回归分析结果显示:口渴喜冷、腰酸腿软、脉数、脉洪与疗效负相关,脉细、苔薄白与疗效正相关。2.诱导排卵失败患者的中医证型分布为热盛津伤型占40.00%、肝郁化热占32.78%、肾阴虚内热型占27.22%,成功组患者的中医证型分布为阳虚兼肝郁占91.43%、阴津亏虚占1.43%、阴虚化热占2.86%、肝郁兼热盛占4.29%。结论:1.中医四诊信息与诱导排卵疗效具有明显的相关性,对诱导排卵疗效具有预测价值。2.两组均有各自的中医证型分布规律,中医辨证对诱导排卵疗效具预测价值。
[Abstract]:Objective: to investigate the distribution of syndromes related to the efficacy of HMG induced ovulation and the clinical diagnostic value of ulnar skin diagnosis. To provide syndromes basis and syndrome differentiation for patients with ovulatory disorder infertility of various clinical epiderms whether to take HMG to promote ovulation treatment and how to choose the best follow-up treatment scheme after failure. Methods: four diagnoses of symptoms, tongue and pulse were collected in 70 cases of successful ovulation induced by urotropin (HMG) and 180 cases of failure. Logistic regression analysis, factor analysis and cluster analysis were performed. The result is 1: 1. There were significant differences in four-diagnosis information between the two groups. The results of multiple regression analysis showed that: thirst and cold, weak waist and leg, pulse number, pulse flood were negatively correlated with curative effect, pulse size, thin fur and white fur were positively correlated with curative effect. 2. The distribution of TCM syndromes of failed ovulation patients was heat Shengjin injury (40.00g), liver depression and heat (32.78m), kidney yin deficiency (27.22g). In successful group, the TCM syndromes were Yang deficiency and liver depression (91.43%), Yin deficiency (1.43%), Yin deficiency heat (2.86%), liver depression and heat (4.2929%). Conclusion 1. The information of four diagnoses of TCM has a significant correlation with the effect of ovulation induction, and has predictive value. 2. 2. The two groups have their own distribution of TCM syndromes, TCM syndrome differentiation can predict the efficacy of ovulation induction.
【学位授予单位】：河北大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R711.6

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