影响人工授精妊娠率的多因素分析

发布时间：2018-07-27 14:54

【摘要】：目的:探讨影响夫精人工授精妊娠率的相关因素。方法:选取2013年3月至2014年9月在南通大学附属医院生殖医学中心行宫腔内人工授精(IUI)治疗的夫妇146对,共277个周期。分析女性年龄、不孕年限、IUI治疗周期数、促排卵方案,扳机方法及扳机日相关指标等与临床妊娠率的关系。结果:年龄25岁组的妊娠率明显高于年龄30岁组(25.8%vs 11.2%,P0.05);妊娠组的扳机日促黄体生成素(LH)水平高于非孕组[(29.7±8.44)vs(16.6±1.52),P0.05]。子宫内膜分型为A型者的妊娠率显著高于非A型者(P0.05)。GnRH-a扳机后排卵率优于HCG(P0.05);4个治疗周期内随着周期数的增加累计妊娠率上升,卵泡期为10~16天妊娠率最高。结论:夫精人工授精治疗中,患者年龄、HCG日LH值、子宫内膜分型与妊娠率相关,GnRH-a扳机后排卵率优于HCG。
[Abstract]:Objective: to investigate the related factors affecting the pregnancy rate of artificial insemination. Methods: from March 2013 to September 2014, 146 couples treated with intrauterine artificial insemination (IUI) in the Center of Reproductive Medicine, affiliated Hospital of Nantong University, were selected for 277 cycles. The relationship between the clinical pregnancy rate and the age of women, the number of IUI treatment cycles, the plan of ovulation promotion, the trigger method and the relevant indexes of trigger date were analyzed. Results: the pregnancy rate of 25 years old group was significantly higher than that of 30 years old group (25.8%vs 11.2 P 0.05), and the level of luteinizing hormone (LH) in pregnancy group was higher than that in non-pregnancy group [(29.7 卤8.44) vs (16.6 卤1.52) P 0.05]. The pregnancy rate of type A group was significantly higher than that of non-type A group (P0.05) .GnRH-a trigger ovulation rate was higher than that of HCG (P0.05), and the cumulative pregnancy rate increased with the increase of the number of cycles in four treatment cycles, and the pregnancy rate of follicular phase was the highest at 10 ~ 16 days. Conclusion: in the treatment of artificial insemination, the age of patients with HCG, endometrial classification and pregnancy rate were significantly higher than that of HCG after GnRH-a trigger.
【作者单位】：南通大学附属医院生殖医学中心;南通大学实验动物中心;
【分类号】：R714.8

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