子痫前期相关高危因素的临床研究

发布时间：2018-07-28 18:01

【摘要】：目的分析子痫前期与正常孕妇相关指标的差异,探讨子痫前期发病的高危因素。方法选取2004年4月至2014年4月产科住院的子痫前期产妇2 180例作为研究组,选择同期住院正常产妇2 980例作为对照组。收集2组孕妇年龄、孕前体重指数(BMI)、孕期增重、入组时的血压、空腹血糖(FPG)、三酰甘油(TG)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)、载脂蛋白-A1(Apo A1)和载脂蛋白-B(Apo B)进行分析。结果研究组孕前BMI、孕期增重分别为(25.11±4.03)kg/m2和(19.28±3.36)kg,与对照组(21.27±2.43)kg/m2和(14.52±2.33)kg比较,差异有统计学意义(P0.05)。研究组孕妇入组时收缩压、舒张压分别为(147.25±14.22)mm Hg和(100.55±10.98)mm Hg,对照组分别为(109.65±11.33)mm Hg和(69.51±8.06)mm Hg,2组比较,差异均有统计学意义(P0.01)。研究组FPG、TG和Apo B分别为(4.95±1.98)mmol/L、(4.42±1.83)mmol/L和(1.18±0.38)g/L,对照组分别为(3.54±1.03)mmol/L、(3.33±1.22)mmol/L和(1.01±0.22)g/L,两2组比较,差异均有统计学意义(P0.05)。logistic回归分析显示:孕前BMI(OR值9.85)、孕期增重(OR值5.17)、FPG(OR值6.48)、TG(OR值6.45)、Apo B(OR值6.98)、年龄(OR值5.58)及平均动脉压(OR值5.27)均为子痫前期发病的危险因素(P0.05)。结论子痫前期的发病与多因素相关,其中孕前BMI、孕期增重、FPG、TG、Apo B、年龄及平均动脉压是罹患子痫前期的危险因素。
[Abstract]:Objective to study the high risk factors of preeclampsia by analyzing the difference between preeclampsia and normal pregnant women. Methods from April 2004 to April 2014, 2 180 cases of preeclampsia in obstetrics department were selected as study group and 2 980 cases of normal pregnant women in the same period as control group. Age, body mass index (BMI),) during pregnancy, blood pressure, fasting blood glucose, (FPG), triglyceride (TG), low density lipoprotein (LDL-C), high density lipoprotein (HDL-C), apolipoprotein A 1 (Apo A1) and apolipoprotein B (Apo B) were analyzed. Results the weight gain during pregnancy was (25.11 卤4.03) kg/m2 and (19.28 卤3.36) kg in the study group, which was significantly higher than that in the control group (21.27 卤2.43) kg/m2 and (14.52 卤2.33) kg (P0.05). Systolic blood pressure (SBP) and diastolic blood pressure (DBP) were (147.25 卤14.22) mm Hg) and (100.55 卤10.98) mm Hg,) in the study group (109.65 卤11.33) mm Hg and (69.51 卤8.06) mm), respectively. There were significant differences between the two groups (P0.01). The TG and Apo B of the study group were (4.95 卤1.98) mmol / L, (4.42 卤1.83) mmol/L and (1.18 卤0.38) g / L, respectively, and those of the control group were (3.54 卤1.03) mmol / L, (3.33 卤1.22) mmol/L and (1.01 卤0.22) g / L, respectively. The differences were statistically significant (P0.05). Logistic regression analysis showed that BMI (OR before pregnancy (OR 5.17), weight gain during pregnancy (OR 6.48), TG (OR 6.45) and Apo B (OR (6.98), age (OR 5.58) and mean arterial pressure (OR 5.27) were the risk factors of preeclampsia (P0.05). Conclusion the incidence of preeclampsia is related to many factors, among which BMI before pregnancy, FPGG TGG Apo B during pregnancy, age and mean arterial pressure are risk factors of preeclampsia.
【作者单位】：河北省秦皇岛市妇幼保健院;河北省秦皇岛市工人医院;
【分类号】：R714.244

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