妊娠合并亚临床甲状腺功能减退患者碘营养状况和甲状腺自身抗体水平调查
发布时间：2018-08-02 15:13
【摘要】：目的：分析妊娠期间碘营养、甲状腺自身抗体与甲状腺功能的关系。 方法：电化学发光法检测140名妊娠女性甲状腺功能及甲状腺过氧化物酶抗体（TPOAb）、甲状腺球蛋白抗体（TgAb）水平，根据血清促甲状腺激素（TSH）及游离甲状腺素（FT4）水平分为正常组(n=117)和亚临床甲状腺功能减退组(n=23)。甲状腺触诊了解是否甲状腺肿。应用尿碘砷铈催化分光光度法检测孕妇尿碘水平。调查甲状腺功能异常组既往甲状腺病史知晓情况。使用EXCEL软件收集数据，应用SPSS19.0对数据进行分析。 结果：①正常组与亚临床甲状腺功能减退组分别有50%、57%的女性具有不同程度碘缺乏。②尿碘水平与甲状腺功能无显著相关。③血清TPOAb、TgAb水平与血清TSH显著相关，TPOAb水平与血清FT4显著相关。④甲状腺功能异常者中70%孕前未行甲状腺功能及自身抗体筛查，8.7%否认既往甲状腺疾病史，21.7%既往有甲状腺功能减退。 结论：甲状腺自身抗体为亚临床甲状腺功能减退发生的主要危险因素，支持孕前或孕早期常规筛查尿碘及甲状腺自身抗体,及时纠正碘缺乏，，并避免盲目过量补碘，改善围产期结局，以减少对亲子的不利影响。
[Abstract]:Objective: to analyze the relationship between iodine nutrition, thyroid autoantibodies and thyroid function during pregnancy. Methods: the thyroid function of 140 pregnant women and the level of thyroid peroxidase antibody (TPOAb),) thyroglobulin antibody (TgAb) were detected by electrochemiluminescence (ECL). According to the levels of serum thyrotropin (TSH) and free thyroxine (FT4), they were divided into normal group and subclinical hypothyroidism group. Thyroid palpation to see if goiter. Urine iodine level of pregnant women was determined by catalytic spectrophotometry with iodide, arsenic and cerium. To investigate the knowledge of thyroid history in patients with abnormal thyroid function. EXCEL software is used to collect data and SPSS19.0 is used to analyze the data. Results there was no significant correlation between urinary iodine deficiency and thyroid function. 3 serum TPO Ab level and serum TSH level in 50% of women with normal and subclinical hypothyroidism. There was a significant correlation between serum FT4 and thyroid function in 70% of the patients with abnormal thyroid function before pregnancy and 8. 7% of them denied that there was a history of thyroid disease and 21. 7% had past hypothyroidism. Conclusion: thyroid autoantibodies are the main risk factors for subclinical hypothyroidism, which supports routine screening of urinary iodine and thyroid autoantibodies before pregnancy or early pregnancy, in order to correct iodine deficiency in time and avoid blind overdose of iodine. Improve perinatal outcomes to reduce adverse effects on parentage.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R714.256
本文编号：2159840
[Abstract]:Objective: to analyze the relationship between iodine nutrition, thyroid autoantibodies and thyroid function during pregnancy. Methods: the thyroid function of 140 pregnant women and the level of thyroid peroxidase antibody (TPOAb),) thyroglobulin antibody (TgAb) were detected by electrochemiluminescence (ECL). According to the levels of serum thyrotropin (TSH) and free thyroxine (FT4), they were divided into normal group and subclinical hypothyroidism group. Thyroid palpation to see if goiter. Urine iodine level of pregnant women was determined by catalytic spectrophotometry with iodide, arsenic and cerium. To investigate the knowledge of thyroid history in patients with abnormal thyroid function. EXCEL software is used to collect data and SPSS19.0 is used to analyze the data. Results there was no significant correlation between urinary iodine deficiency and thyroid function. 3 serum TPO Ab level and serum TSH level in 50% of women with normal and subclinical hypothyroidism. There was a significant correlation between serum FT4 and thyroid function in 70% of the patients with abnormal thyroid function before pregnancy and 8. 7% of them denied that there was a history of thyroid disease and 21. 7% had past hypothyroidism. Conclusion: thyroid autoantibodies are the main risk factors for subclinical hypothyroidism, which supports routine screening of urinary iodine and thyroid autoantibodies before pregnancy or early pregnancy, in order to correct iodine deficiency in time and avoid blind overdose of iodine. Improve perinatal outcomes to reduce adverse effects on parentage.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R714.256
【参考文献】
相关期刊论文 前1条
1 李晨阳,滕卫平,尚涛;甲状腺激素与妊娠[J];中华内分泌代谢杂志;2003年02期
本文编号：2159840
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