松奇贴片治疗围绝经期综合征124例疗效分析

发布时间：2018-08-05 11:23

【摘要】：目的探讨半水合雌二醇贴片(商品名松奇)治疗围绝经期综合征的临床疗效。方法 2009年12月至2011年6月应用多中心前瞻性研究方法在全国4家医院共纳入124例绝经后妇女,给予松奇贴片24周治疗,有子宫者加用孕激素,于治疗第4、12、24周检测血清雌二醇(E2)水平,并进行Kupperman评分以评价更年期症状,同时记录乳房胀痛、阴道流血和皮肤过敏等不良反应。结果 (1)生殖激素水平:E2在治疗前为(61.09±50.33)pmol/L,治疗4周时上升为(198.85±307.29)pmol/L(P=0.0003);治疗12周时进一步上升至(258.87±220.40)pmol/L(P=0.0001);治疗24周时为(219.86±190.21)pmol/L(P=0.0000)。(2)Kupperman评分:治疗前Kupperman评分为23.91±8.11,治疗4周后,Kupperman评分较基线时大大下降,为9.05±7.56(P=0.0000);治疗12周时,Kupperman评分又进一步下降,为5.73±5.42(P=0.0000);治疗24周时,Kupperman评分基本维持不变,为5.76±7.03(P=0.0000)。(3)研究期间未观察到严重副反应。结论松奇贴片单独使用或加用口服微粒化孕酮或地屈孕酮能安全有效缓解围绝经期综合征。
[Abstract]:Objective to investigate the clinical effect of semi-hydrate estradiol patch (trade name Songqi) in the treatment of perimenopausal syndrome. Methods from December 2009 to June 2011, 124 postmenopausal women in 4 hospitals were treated with Songqi patch for 24 weeks, and those with uterus were treated with progesterone. Serum estradiol (E _ 2) levels were measured at the 24th week of treatment and Kupperman score was used to evaluate menopausal symptoms. Adverse reactions such as breast pain vaginal bleeding and skin allergy were recorded at the same time. Results (1) the reproductive hormone level was (61.09 卤50.33) pmol / L before treatment, increased to (198.85 卤307.29) pmol/L (P0. 0003) at 4 weeks, further increased to (258.87 卤220.40) pmol/L (P0. 0001) at 12 weeks, and (219.86 卤190.21) pmol/L (P0. 0000). (2) Kupperman score at 24 weeks: Kupperman score was 23.91 卤8. 11 before treatment and decreased significantly after 4 weeks of treatment. After 12 weeks of treatment, the Kupperman score was further decreased to 5.73 卤5.42 (P0. 0000), and the Kupperman score remained unchanged at 24 weeks (5.76 卤7. 03 (P0. 0000). (3). Conclusion Songqi patch alone or in combination with oral parvoprogesterone or diproprogesterone is safe and effective in relieving perimenopausal syndrome.
【作者单位】：复旦大学附属妇产科医院;中国医学科学院北京协和医院;首都医科大学附属北京妇产医院;四川大学华西第二医院;
【分类号】：R711.75

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