GPR30阳性表达对子宫内膜癌患者预后的影响及其与雌、孕激素受体表达的相关性

发布时间：2018-08-09 08:49

【摘要】：目的分析新型雌激素受体GPR30表达对子宫内膜癌患者预后的影响并探讨其与雌、孕激素表达的关系。方法收集该院妇产科经病理确诊为子宫内膜癌的石蜡切片,采用免疫组化法检测GPR30、雌激素受体、孕激素受体表达,并分析其对子宫内膜癌的临床意义和分析三者间的关系。结果 GPR30阳性表达率与子宫内膜癌的FIGO分期、组织分级以及肌层浸润深度有关联(P0.05),与淋巴结转移无明显相关性(P0.05)。GPR30表达阳性率在子宫内膜癌中表达显著高于增殖期子宫内膜(P0.05),PR表达阳性率在子宫内膜癌与增殖期子宫内膜差异显著(P0.05),ER表达阳性率在两者间无差异(P0.05)。子宫内膜癌GPR30与ER阳性共表达率为61.2%(30/49),呈正相关(r=0.315,P=0.021);与PR阳性共表达率为57.1%(28/49),呈正相关(r=0.303,P=0.027)。结论 GPR30阳性表达对子宫内膜癌的病理分期、组织分级以及肌层浸润深度相关,对子宫内膜癌预后产生重要作用;GPR30与ER、PR间存在共表达的交谈或调节作用。
[Abstract]:Objective to investigate the effect of novel estrogen receptor (GPR30) expression on the prognosis of endometrial carcinoma and its relationship with estrogen and progesterone expression. Methods paraffin sections of endometrial carcinoma diagnosed by pathology in gynecology and obstetrics department were collected, and the expression of GPR30, estrogen receptor and progesterone receptor were detected by immunohistochemical method. The clinical significance of GPR30, estrogen receptor and progesterone receptor in endometrial carcinoma were analyzed. Results the positive expression rate of GPR30 was correlated with the FIGO stage of endometrial carcinoma. Tissue grade and depth of myometrial invasion were correlated (P0.05), but there was no significant correlation between GPR30 expression and lymph node metastasis (P0.05). The positive rate of GPR30 expression in endometrial carcinoma was significantly higher than that in proliferative endometrial carcinoma (P0.05). The positive rate of PR expression in endometrial carcinoma and proliferative phase was significantly higher than that in proliferative endometrial carcinoma (P0.05). There was no significant difference in ER expression between endometrium and endometrium (P0.05). The coexpression rate of GPR30 and ER in endometrial carcinoma was 61.2% (30 / 49), which was positively correlated with PR (57.1%, 28 / 49) and with PR (0.303%, 0.027). Conclusion the positive expression of GPR30 is related to the pathological stage, histological grade and depth of myometrial invasion in endometrial carcinoma, and plays an important role in the prognosis of endometrial carcinoma.
【作者单位】：武汉科技大学附属汉阳医院妇产科;
【分类号】：R737.33

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