NF-κBp65、TNF-α在妊娠期糖尿病患者中高表达

发布时间：2018-08-09 17:08

【摘要】：目的探讨核转录因子-κBp65(NF-κBp65)、肿瘤坏死因子-α(TNF-α)在妊娠期糖尿病患者中的表达水平及意义。方法收集张家港市中医医院分娩的250例孕产妇的临床资料,将合并有妊娠期糖尿病的97例患者作为研究组,153例正常孕妇作为对照组,对两组孕妇血清和脐血中NF-κBp65、TNF-α的表达水平及在胎盘组织中的阳性率进行对比分析。结果研究组血清和脐血中NF-κBp65水平为(875.66±148.67)、(880.72±151.57)ng/L,明显高于对照组的(312.39±95.38)、(327.84±94.23)ng/L;且研究组血清和脐血中TNF-α水平为(7.72±0.23)、(8.17±0.36)ng/L,亦明显高于对照组的(5.54±0.59)、(5.79±0.43)ng/L,差异均有统计学意义(P0.05)。两组胎盘组织中均可见NF-κBp65和TNF-α阳性颗粒表达,研究组NF-κBp65和TNF-α阳性率分别为92.78%和95.88%,明显高于对照组22.88%和13.73%(P0.05)。结论妊娠期糖尿病孕妇NF-κBp65和TNF-α炎症因子的表达阳性率较正常孕妇高,提示二者对妊娠期糖尿病发生有一定的促进作用。
[Abstract]:Objective to investigate the expression of nuclear factor- 魏 Bp65 (NF- 魏 Bp65) and tumor necrosis factor- 伪 (TNF- 伪) in gestational diabetes mellitus (GDM). Methods the clinical data of 250 pregnant women who were delivered in Zhangjiagang traditional Chinese Medicine Hospital were collected. The 97 pregnant women with gestational diabetes mellitus were used as the study group and 153 normal pregnant women as the control group. The expression level of NF- 魏 B p65 TNF- 伪 in serum and umbilical cord blood and the positive rate in placenta were compared between the two groups. Results the levels of NF- 魏 Bp65 in serum and umbilical blood in the study group were (875.66 卤148.67), (卤151.57) ng / L, significantly higher than those in the control group (312.39 卤95.38), (327.84 卤94.23) ng / L, and the levels of TNF- 伪 in serum and cord blood of the study group were (7.72 卤0.23), (8.17 卤0.36 ng / L, which were significantly higher than those in the control group (5.54 卤0.59), (5.79 卤0.43), respectively (P0.05). The positive rates of NF- 魏 Bp65 and TNF- 伪 in the study group were 92.78% and 95.88% respectively, which were significantly higher than those in the control group (22.88% and 13.73%, P0.05). Conclusion the positive rate of NF- 魏 Bp65 and TNF- 伪 inflammatory factors in pregnant women with gestational diabetes mellitus is higher than that in normal pregnant women.
【作者单位】：张家港市中医医院妇产科;江苏省苏州市立医院;
【分类号】：R714.256

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