子宫颈浸润性癌组织中α-SMA和FAP表达及临床意义
发布时间：2018-08-10 17:04
【摘要】：目的探讨α-平滑肌肌动蛋白(ɑ-smooth muscle actin,α-SMA)、成纤维细胞活化蛋白(fibroblast-activating protein,FAP)在正常子宫颈、子宫颈上皮内瘤变(cervical intraepithelial neoplasias,CIN)、子宫颈浸润性癌组织的表达,并分析二者表达与子宫颈浸润性癌临床病理指标、浸润转移及预后的关系。方法应用免疫组化Eli Vision两步法检测20例正常子宫颈、20例CIN及98例子宫颈浸润性癌组织中α-SMA和FAP的表达。比较三组中α-SMA和FAP的表达水平,以及二者与子宫颈浸润性癌临床病理特征的相关性。结果α-SMA和FAP在正常子宫颈、CIN中不表达,二者在子宫颈浸润性癌中均表达于肿瘤间质成纤维细胞的胞质内,FAP在肿瘤细胞中有少量表达。α-SMA在子宫颈浸润性癌间质中的阳性率为82.7%(81/98),与临床分期、病理分级和淋巴结转移相关(P0.05);FAP在子宫颈浸润性癌间质中的阳性率为79.6%(78/98),FAP表达与子宫颈浸润性癌的临床分期、病理分级和淋巴结转移相关(P0.05);α-SMA和FAP均与患者年龄、肿瘤大小无关(P0.05)。α-SMA和FAP在子宫颈浸润性癌组织标本中表达在区域上有一致性,在表达强度上呈明显正相关。经直线相关分析α-SMA和FAP呈直线相关(r=0.829,P=0.000)。结论α-SMA和FAP在子宫颈浸润性癌生长、浸润和转移方面发挥一定作用,可作为预测子宫颈浸润性癌预后的可靠指标。
[Abstract]:Objective to investigate the expression of 伪 -smooth muscle actin (伪 -SMA) and fibroblast-activating protein in normal cervix, cervical intraepithelial neoplasia (cervical intraepithelial neoplasias cin) and invasive cervical carcinoma. The relationship between the expression and clinicopathological parameters, invasion and metastasis and prognosis of invasive cervical carcinoma was analyzed. Methods the expression of 伪 -SMA and FAP in 20 cases of normal cervical carcinoma and 98 cases of invasive carcinoma of cervix were detected by immunohistochemical Eli Vision two-step method. To compare the expression of 伪 -SMA and FAP in the three groups and their correlation with the clinicopathological features of invasive cervical carcinoma. Results 伪 -SMA and FAP were not expressed in cin of normal cervical carcinoma. Both of them were expressed in the cytoplasm of the interstitial fibroblasts of cervical carcinoma. The positive rate of 伪 -SMA was 82.7% (81 / 98), and the positive rate of 伪 -SMA was 82.7% (81 / 98), and the positive rate of 伪 -SMA was 82.7% (81 / 98) in the stroma of cervical invasive carcinoma, and the positive rate of 伪 -SMA was 82.7% (81 / 98), which was correlated with the clinical stage. Pathological grade and lymph node metastasis correlated (P0.05) the positive rate of FAP was 79.6% (78 / 98) in the interstitial of invasive carcinoma of the cervix and correlated with clinical stage, pathological grade and lymph node metastasis (P0.05), 伪 -SMA and FAP were correlated with the age of the patients. There was no significant difference in tumor size (P0.05). 伪 -SMA and FAP expression were consistent in the region and positively correlated with the expression intensity in invasive cervical carcinoma. The linear correlation between 伪 -SMA and FAP was linear (r = 0.829, P = 0.000). Conclusion 伪 -SMA and FAP may play a certain role in the growth, invasion and metastasis of invasive cervical carcinoma, and can be used as a reliable index to predict the prognosis of invasive cervical carcinoma.
【作者单位】： 吉林省通化市人民医院病理科;北华大学基础医学院病理教研室;
【分类号】：R737.33
本文编号：2175599
[Abstract]:Objective to investigate the expression of 伪 -smooth muscle actin (伪 -SMA) and fibroblast-activating protein in normal cervix, cervical intraepithelial neoplasia (cervical intraepithelial neoplasias cin) and invasive cervical carcinoma. The relationship between the expression and clinicopathological parameters, invasion and metastasis and prognosis of invasive cervical carcinoma was analyzed. Methods the expression of 伪 -SMA and FAP in 20 cases of normal cervical carcinoma and 98 cases of invasive carcinoma of cervix were detected by immunohistochemical Eli Vision two-step method. To compare the expression of 伪 -SMA and FAP in the three groups and their correlation with the clinicopathological features of invasive cervical carcinoma. Results 伪 -SMA and FAP were not expressed in cin of normal cervical carcinoma. Both of them were expressed in the cytoplasm of the interstitial fibroblasts of cervical carcinoma. The positive rate of 伪 -SMA was 82.7% (81 / 98), and the positive rate of 伪 -SMA was 82.7% (81 / 98), and the positive rate of 伪 -SMA was 82.7% (81 / 98) in the stroma of cervical invasive carcinoma, and the positive rate of 伪 -SMA was 82.7% (81 / 98), which was correlated with the clinical stage. Pathological grade and lymph node metastasis correlated (P0.05) the positive rate of FAP was 79.6% (78 / 98) in the interstitial of invasive carcinoma of the cervix and correlated with clinical stage, pathological grade and lymph node metastasis (P0.05), 伪 -SMA and FAP were correlated with the age of the patients. There was no significant difference in tumor size (P0.05). 伪 -SMA and FAP expression were consistent in the region and positively correlated with the expression intensity in invasive cervical carcinoma. The linear correlation between 伪 -SMA and FAP was linear (r = 0.829, P = 0.000). Conclusion 伪 -SMA and FAP may play a certain role in the growth, invasion and metastasis of invasive cervical carcinoma, and can be used as a reliable index to predict the prognosis of invasive cervical carcinoma.
【作者单位】： 吉林省通化市人民医院病理科;北华大学基础医学院病理教研室;
【分类号】：R737.33
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