PTU免疫疗法在治疗妊娠合并甲亢中对母婴的影响研究

发布时间：2018-08-15 16:04

【摘要】：目的本研究旨在发现妊娠合并甲亢孕妇在使用PTU治疗过程中对母婴的影响,包括母体及幼体TSH、TT3、TT4指标的变化以及对围孕妇产期的影响,以便更合理的指导PTU药物治疗妊娠合并甲亢。方法 31名妊娠合并甲亢患者为自2008年至2014年来本院治疗的孕妇,其中实验组16名孕妇采用PTU治疗方案,对照组15名孕妇采用停药保守观察治疗法,在治疗过程中对孕产期患者进行TSH、TT3、TT4、FT3、FT4指标的测定以及围产期的检测。结果统计学分析结果证实使用PTU疗法能够有效治疗妊娠合并甲亢孕妇的病情,治疗组孕妇TSH水平升高至正常水平,TT3、TT4指标下降至正常水平,且婴儿体内TSH、TT3、TT4指标正常,对照组孕妇体内TSH指标持续低下,其中一名患者病情严重,终止妊娠,对照组中3名婴儿受到母体影响,TSH水平降低,有患甲亢的风险。结论丙基硫氧嘧啶(PTU)通过胎盘的量非常少,对孕妇及婴儿的副作用较少,因而作为临床上普遍使用的治疗妊娠合并甲亢的指导药物。
[Abstract]:Objective to find out the effect of PTU therapy on mother and child in pregnant women with hyperthyroidism, including the changes of maternal and infant TSHTT3 TT4 indexes and the effect on the perinatal period of pregnant women. In order to guide more reasonable PTU drug treatment of pregnancy with hyperthyroidism. Methods Thirty-one pregnant women with hyperthyroidism were treated in our hospital from 2008 to 2014. 16 pregnant women in the experimental group were treated with PTU regimen, while 15 pregnant women in the control group were treated with conservative observation therapy. In the course of treatment, the parameters of TSHTT _ 3T _ 4T _ 4T _ 3T _ 4 and perinatal period were measured in pregnant and parturient patients. Results the results of statistical analysis showed that PTU therapy could effectively treat the condition of pregnant women with hyperthyroidism. The TSH level of pregnant women in the treatment group increased to the normal level and the level of TT3T4 decreased to the normal level, and the TSHTT3T4 index was normal in infants. The levels of TSH in pregnant women in the control group were continuously low, one of them was in severe condition and terminated pregnancy, and 3 infants in the control group were at risk of hyperthyroidism due to the maternal influence. Conclusion the amount of propylthiouracil (PTU) passing through the placenta is very small, and the side effects on pregnant women and infants are less, so it is widely used in clinic to treat pregnancy with hyperthyroidism.
【作者单位】：浙江慈溪市人民医院妇产科;
【分类号】：R714.256

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