妊娠期不良妊娠结局和不同孕期弓形虫和风疹病毒及巨细胞病毒和单纯疱疹病毒感染的关系

发布时间：2018-08-18 15:38

【摘要】：目的观察妊娠期不良妊娠结局和孕早期及孕中晚期TORCH感染的相关性,为临床治疗提供依据。方法选择医院2014-2015年有不良妊娠结局孕产妇150例为观察组,同期选择无不良妊娠结局孕产妇150例为对照组,两组早期妊娠孕产妇100例,中晚期妊娠孕产妇50例,采用酶联免疫吸附实验测定血清弓形虫、风疹病毒、巨细胞病毒和单纯疱疹病毒IgG和IgM抗体。结果观察组孕早期和孕中晚期弓形虫、风疹病毒、巨细胞病毒和单纯疱疹病毒IgG阳性率均高于对照组;观察组孕早期和孕中晚期弓形虫、风疹病毒、巨细胞病毒和单纯疱疹病毒IgM阳性率均高于对照组(P0.05);观察组孕早期和孕中晚期弓形虫、风疹病毒、巨细胞病毒和单纯疱疹病毒IgG+IgM阳性率均高于对照组,差异均有统计学意义(P0.05)。结论妊娠期不良妊娠结局和孕早期及孕中晚期TORCH感染关系密切,孕前及孕期进行TORCH筛查对降低妊娠期不良妊娠结局具有重要意义。
[Abstract]:Objective to investigate the relationship between the adverse pregnancy outcome and TORCH infection in early and third trimester of pregnancy. Methods 150 pregnant women with adverse pregnancy outcome were selected as observation group, 150 pregnant women without adverse pregnancy outcome were selected as control group, 100 pregnant women with early pregnancy and 50 pregnant women with intermediate and late pregnancy were selected as control group. Serum antibodies to Toxoplasma gondii, rubella virus, cytomegalovirus and herpes simplex virus IgG and IgM were determined by enzyme-linked immunosorbent assay (Elisa). Results the positive rates of Toxoplasma gondii, rubella virus, cytomegalovirus and herpes simplex virus IgG in the observation group were higher than those in the control group, and the positive rates of Toxoplasma gondii and rubella virus in the observation group were higher than those in the control group. The positive rates of cytomegalovirus (CMV) and herpes simplex virus (IgM) were higher in the observation group than in the control group (P0.05), and the positive rates of Toxoplasma gondii, rubella virus, cytomegalovirus and herpes simplex virus IgG IgM in the observation group were higher than those in the control group (P0.05). Conclusion there is a close relationship between the adverse pregnancy outcome and TORCH infection in the early and third trimester of pregnancy. TORCH screening before and during pregnancy is of great significance in reducing the adverse pregnancy outcome.
【作者单位】：湖州市中心医院妇产科;
【基金】：2014年浙江省医药卫生一般研究计划项目(2014KYB254)
【分类号】：R714.25

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