原发不孕及复发性流产女性血清泌乳素与NK细胞相关性分析

发布时间：2018-08-18 16:55

【摘要】：目的探讨原发性不孕及复发性流产(RSA)女性血清泌乳素(PRL)水平与自然杀伤(NK)细胞的相关性。方法研究对象为原发性不孕组90例,RSA组90例,并同期选择生育女性90例为对照组,应用电化学发光法测定血清PRL,TSH,FSH,LH和E2,流式细胞术测定NK细胞百分比,分析血清PRL与NK细胞是否相关。结果原发性不孕、RSA组血清PRL水平均高于对照组(P0.05),原发性不孕、RSA组中HPRL率均高于对照组(P0.05),原发性不孕及RSA组中,PRL与NK细胞百分比密切相关,为独立相关因素(P0.05),原发不孕与RSA组中HPRL的女性,PRL与NK细胞百分比为正相关(P0.05)。结论原发性不孕和RSA女性中,PRL水平和NK细胞存在相互作用,HPRL可作为直接刺激因子导致NK细胞百分比升高。
[Abstract]:Objective to investigate the relationship between serum prolactin (PRL) level and natural killer (NK) cells in (RSA) women with primary infertility and recurrent abortion. Methods 90 cases of primary infertility group and 90 cases of fertile female group were selected as control group. Serum PRL TSHSHFSHFSHLH LH and E2 were measured by electrochemiluminescence (ECL), and NK cell percentage was measured by flow cytometry (FCM). The relationship between serum PRL and NK cells was analyzed. Results the level of serum PRL in primary infertility group was higher than that in control group (P0.05), and the HPRL rate in primary infertility group was higher than that in control group (P0.05). The percentage of NK cells in primary infertility group and RSA group was closely related to the percentage of NK cells. There was a positive correlation between the percentage of HPRL and NK cells in the primary infertility group and RSA group (P0.05). Conclusion there is interaction between PRL level and NK cells in women with primary infertility and RSA. HPRL can be used as a direct stimulator to increase the percentage of NK cells.
【作者单位】：河北医科大学第四医院生殖医学科;河北省深州市医院;河北省胸科医院;
【基金】：河北省医学科学研究课题计划(项目编号:20160626)
【分类号】：R711.6;R714.21

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