宫颈癌患者腔内同步放化疗与局部感染危险因素及疗效的研究

发布时间：2018-08-18 19:48

【摘要】：目的探讨同步放化疗治疗中晚期宫颈癌的临床效果,分析宫颈癌并发局部感染的危险因素。方法选择2010年1月-2011年1月于医院就诊的中晚期宫颈癌患者60例,随机分为观察组和对照组,各30例,对照组给予单纯放射治疗,观察组给予同步放化疗治疗,比较两组近期疗效及不良反应,随访5年,比较两组近远期疗效,分析感染相关影响因素。结果观察组近期总有效率为93.33%显著高于对照组的73.33%(P0.05),观察组5年生存率为76.67%显著高于对照组的53.33%(P0.05);观察组局部复发率及远处转移率分别为16.67%,13.33%显著低于对照组33.33%,26.67%(P0.05);对照组不良反应发生率13.33%,与观察组23.33%差异无统计学意义。观察组发生局部感染20例,感染率为66.67%;住院时间7d、合并有基础疾病、医护人员的手术不熟练、尿管留置时间3d、未应用抗菌药物、FIGO分期IVb期是宫颈癌患者腔内放疗并发局部感染的独立危险因素(P0.05)。结论对中晚期宫颈癌患者采取同步放化疗治疗的疗效较好,提高患者生存率,且耐受性较好。
[Abstract]:Objective to investigate the clinical effect of concurrent radiotherapy and chemotherapy in the treatment of advanced cervical cancer and to analyze the risk factors of cervical cancer complicated with local infection. Methods from January 2010 to January 2011, 60 patients with advanced cervical cancer were randomly divided into two groups: the observation group (n = 30) and the control group (n = 30). The control group was treated with radiotherapy alone, and the observation group was treated with concurrent radiotherapy and chemotherapy. The short term curative effect and adverse reaction were compared between the two groups, followed up for 5 years, the near and long term curative effect were compared, and the influencing factors of infection were analyzed. Results the short-term total effective rate of the observation group was 93.33% significantly higher than that of the control group 73.33% (P0.05), the 5-year survival rate of the observation group was 76.67% significantly higher than that of the control group 53.33% (P0.05), the local recurrence rate and distant metastasis rate of the observation group were 13.33% significantly lower than that of the control group (26.67%), and the control group was significantly lower than the control group (P0.05). The incidence of adverse reaction was 13.33%, and there was no significant difference between observation group and observation group (23.33%). In the observation group, 20 cases of local infection occurred, the infection rate was 66.67%, the hospital stay was 7 days, the patients were complicated with basic diseases, and the medical staff were not skilled in operation. Urinary catheter indwelling time 3 days, no use of antibiotics Figo stage IVb stage of cervical cancer patients with intracavitary radiotherapy associated with local infection of the independent risk factors (P0.05). Conclusion simultaneous radiotherapy and chemotherapy is effective in the treatment of advanced cervical cancer, and the survival rate is improved.
【作者单位】：郑州大学附属肿瘤医院妇瘤科六病区;
【分类号】：R737.33

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