高龄子宫内膜癌患者的综合治疗

发布时间：2018-08-19 07:01

【摘要】：目的分析综合治疗对于高龄子宫内膜癌患者的疗效及生存情况影响。方法回顾性分析2004年3月至2009年5月在该院住院的96例高龄子宫内膜癌患者的临床资料,根据病理特点、临床分期及治疗方法将患者分为单纯手术治疗(36例)、手术加放疗组(22例)、综合治疗组(38例);观察对比患者治疗后的疗效、复发情况。结果 96例患者随访至2014年5月,随访率为89.6%,16例(16.7%)患者死亡失访。按寿命表法计算三组患者的3年、5年生存率(OS)及无瘤生存率(DFS),结果发现3年OS为93.8%,3年DFS为93.8%;5年OS为88.5%,5年DFS为73.6%。21例(21.9%)出现癌症复发,手术加放疗组和综合治疗组的复发率均高于单纯手术组(χ2=5.047,P0.05)。手术加放疗组和综合治疗组患者的5年OS及DFS均高于单纯手术组(P0.05),但手术加放疗组与综合治疗组两组间的5年OS及DFS比较无显著差异(P0.05)。结论与单纯手术治疗相比,手术加放疗或综合疗法可显著高龄子宫内膜癌可显著提高患者的5年OS及5年DFS,明显改善患者预后。
[Abstract]:Objective to analyze the curative effect and survival status of comprehensive therapy in elderly patients with endometrial carcinoma. Methods the clinical data of 96 elderly patients with endometrial carcinoma hospitalized in our hospital from March 2004 to May 2009 were retrospectively analyzed. The patients were divided into simple surgical treatment (36 cases), surgery plus radiotherapy group (22 cases) and comprehensive treatment group (38 cases). Results 96 patients were followed up until May 2014. The follow-up rate was 89. 6% (16. 7%). The 3-year survival rate (OS) and tumor-free survival rate (DFS),) of the three groups were calculated according to the life table method. The results showed that the 3-year OS was 93.8, the 3-year DFS was 93.8, the 5-year OS was 88.5m, and the 5-year DFS was 73.6.21 cases (21.9%). The recurrence rate of operation plus radiotherapy group and combined treatment group was higher than that of simple operation group (蠂 2 + 5.047 P 0.05). The 5-year OS and DFS in the surgery plus radiotherapy group and the combined treatment group were higher than those in the simple operation group (P0.05), but there was no significant difference between the operation and radiotherapy group and the combined treatment group in the 5-year OS and DFS (P0.05). Conclusion compared with surgical treatment alone, surgery plus radiotherapy or combined therapy can significantly improve the 5-year OS and 5-year DFS in elderly patients with endometrial carcinoma, and improve the prognosis of the patients.
【作者单位】：宁波市北仑区第一人民医院;
【分类号】：R737.33

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