多囊卵巢综合症患者血清betatrophin水平与胰岛素抵抗的相关性研究

发布时间：2018-08-19 16:38

【摘要】：目的:探讨多囊卵巢综合征(polycystic ovary syndrome,PCOS)患者中betatrophin水平与胰岛素抵抗的相关性。方法:在横断面研究中,纳入了44名PCOS患者和35名健康妇女。计算稳态模型胰岛素抵抗指数(homeostatic model assessment insulin resistance,HOMA-IR)及稳态模型胰岛β细胞功能指数(homeostatic model assessmentβcell function,HOMA-β),并采用酶联免疫吸附法(enzyme-linked immunosorbent assay,ELISA)测定血清betatrophin水平,分析betatrophin与胰岛素抵抗(insulin resistance,IR)的关系。同时观察37名PCOS患者经二甲双胍及罗格列酮钠治疗3个月后上述指标的变化情况。结果:PCOS患者血清betatrophin水平明显低于正常对照组[(0.43±0.15)ng/m L和(1.17±0.57)ng/m L,P=0.000]。相关性分析表明,在PCOS患者中,血清betatrophin水平与空腹血糖(fasting plasma glucose,FPG)、餐后2h血糖(2h postprandial plasma glucose,2h PG)、空腹胰岛素(fasting insulin,FINS)、HOMA-IR、超敏C反应蛋白(high-sensitivity C-reactive protein,hs-CRP)水平呈负相关(r=-0.331,r=-0.372,r=-0.311,r=-0.337,r=-0.338,均P0.05)。多元逐步回归分析显示,在PCOS患者中,HOMA-IR是betatrophin的独立影响因素(P0.05)。罗格列酮+二甲双胍治疗3个月后,PCOS患者betatrophin浓度较其基线值升高[(0.87±0.51)ng/m L和(0.42±0.17)ng/m L,P=0.000]。结论:PCOS患者存在betatrophin水平明显降低,且与IR负相关。
[Abstract]:Objective: to investigate the correlation between betatrophin level and insulin resistance in patients with polycystic ovary syndrome (polycystic ovary syndrome). Methods: 44 PCOS patients and 35 healthy women were included in the cross-sectional study. Insulin resistance index (homeostatic model assessment insulin resistance index) and islet 尾 cell function index (homeostatic model assessment 尾 cell function HOMA- 尾) were calculated. Serum betatrophin levels were measured by enzyme-linked immunosorbent assay-ELISA. The relationship between betatrophin and insulin resistance (IR) was analyzed. At the same time, 37 patients with PCOS were treated with metformin and rosiglitazone sodium for 3 months. Results the serum betatrophin levels in patients with 1: PCOS were significantly lower than those in normal controls [(0.43 卤0.15) ng/m / L and (1.17 卤0.57) ng/m / L respectively]. Correlation analysis showed that in PCOS patients, the levels of serum betatrophin were negatively correlated with fasting blood glucose (fasting plasma glucose (FPG), 2 h postprandial plasma glucose (2h postprandial plasma insulin ins) and HOMA-IRs, and the levels of high-sensitivity C-reactive protein hs-CRP were negatively correlated (r-0.331r-0.372r-0.311r-0.337r-0.337r-0.338P, respectively). Multiple stepwise regression analysis showed that HOMA-IR was an independent factor of betatrophin in PCOS patients (P0.05). After 3 months of rosiglitazone metformin treatment, the betatrophin levels in patients with PCOS were higher than their baseline values [(0.87 卤0.51) ng/m L and (0.42 卤0.17) ng/m / L]. Conclusion the level of betatrophin was significantly decreased and negatively correlated with IR in patients with 1% PCOS.
【作者单位】：重庆医科大学附属第一医院内分泌科
【基金】：国家自然科学基金资助项目(编号:81270911、81070639、30771038) 中华医学会内分泌学会分会研究经费资助项目国家临床重点专科建设资助项目(编号:170)
【分类号】：R711.75

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