兰州城区孕妇甲状腺功能现况调查

发布时间：2018-08-19 18:51

【摘要】：目的了解兰州城区孕妇甲状腺功能的现状及其影响因素。方法随机选择2014年6月至2016年2月自愿在甘肃省妇幼保健院进行围产保健,并长期居住在兰州市城区的不同孕期孕妇1 127例,测定其空腹静脉血甲状腺功能,包括促甲状腺激素(TSH)、游离甲状腺素(FT4)、甲状腺过氧化物酶抗体(TPOAb)水平及空腹尿碘值。分析甲状腺功能与孕妇年龄、孕周及孕前体质量指数的关系,以及尿碘值与甲状腺功能是否存在联系,各项甲状腺功能指标之间是否存在联系。结果不同年龄孕妇的TSH值之间比较有统计学差异(F=3.202,P=0.007),FT4值之间比较有统计学差异(F=2.508,P=0.029),TPOAb值之间比较无统计学差异(H=2.268,P=0.811)。不同孕期孕妇的TSH值之间比较有统计学差异(F=4.173,P=0.016),FT4值之间比较有统计学差异(F=20.290,P=0.000),TPOAb值之间比较无统计学差异(H=0.136,P=0.934)。不同孕前体重指数孕妇的TSH值之间比较没有统计学差异(F=0.936,P=0.423),FT4值之间比较无统计学差异(F=2.309,P=0.075),TPOAb值之间比较有统计学差异(H=12.333,P=0.006)。尿碘值与TSH值负相关(r=-0.070,P=0.016);尿碘值与FT4值正相关(r=0.187,P=0.000);尿碘值与TPOAb值负相关(r=-0.066,P=0.020)。TSH值与TPOAb值之间正相关(r=0.073,P=0.014),FT4值与TPOAb值之间无相关性(r=-0.016,P=0.597)。结论兰州城区孕妇的甲状腺功能与妊娠年龄、孕期、孕前体重指数、碘营养状况之间存在联系。应当加强这一地区孕妇尿碘及甲状腺功能指标的监测,为提高人口质量提拱了新的思路。
[Abstract]:Objective to investigate the thyroid function of pregnant women in Lanzhou city and its influencing factors. Methods from June 2014 to February 2016, 1 127 pregnant women with different pregnancy were randomly selected to perform perinatal health care in Gansu Provincial Maternal and Child Health Hospital, and their fasting venous thyroid function was measured. It included thyroid stimulating hormone (TSH), free thyroxine (FT4), thyroid peroxidase antibody (TPOAb) level and fasting urinary iodine value. To analyze the relationship between thyroid function and maternal age, gestational weeks and pregestational mass index, whether there is a relationship between urinary iodine value and thyroid function, and whether there is a relationship between each thyroid function index. Results there were significant differences in TSH values among pregnant women of different ages (F = 3.202) and FT _ 4 (F _ (2.508) P ~ (0.029). There was no significant difference in TSH values between pregnant women of different ages (P ~ (0.811). There was statistical difference in TSH between pregnant women with different pregnancy (FF4.173 P0. 016) and FT4 (F20. 290% P0. 000). There was no significant difference in TPOAb between pregnant women and pregnant women (H0. 136, P < 0. 934). There was no significant difference in TSH between pregnant women with different body mass index before pregnancy (F0. 936, P < 0. 423) and FT4 (F = 2. 309, P < 0. 075). There was a significant difference between the TSH values of pregnant women with different body mass index (H0. 12. 333, P = 0. 006), and there was no significant difference between them (F = 2. 309, P < 0. 075, P < 0. 006). Urinary iodine value was negatively correlated with TSH value (r = 0.070), urine iodine value was positively correlated with FT4 value (r = 0.187 P0. 000), urinary iodine value was negatively correlated with TPOAb value (r = 0.066 P0. 020). There was no positive correlation between urinary iodine value and TPOAb value (r = 0. 073 P0. 014) and TPOAb value (r = 0. 016, P = 0. 597). Conclusion there is a correlation between thyroid function and gestational age, body mass index (BMI) and iodine nutritional status of pregnant women in Lanzhou urban area. The monitoring of urine iodine and thyroid function index of pregnant women in this area should be strengthened, and a new way of thinking should be put forward to improve the quality of population.
【作者单位】：甘肃省妇幼保健院围产医学中心;
【基金】：甘肃省科技支撑计划-社会发展类资助项目(目编号:144FKCA068)
【分类号】：R714;R446.1

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