两种微刺激方案在卵巢低反应患者中的应用

发布时间：2018-08-20 11:52

【摘要】：目的:探讨卵巢低反应(poor ovarian response,POR)患者在体外受精/卵胞质内单精子显微注射-胚胎移植(IVF/ICSI-ET)技术中应用微刺激方案更合适的取卵时机。方法:回顾性分析接受微刺激方案IVF/ICSI-ET助孕的POR患者共363个周期的临床资料,分为来曲唑(LE)+尿促性腺素(hMG)+后半程氯米芬片(CC)组(A组)和全程CC+hMG组(B组)。观察分析临床及实验室指标、不同取卵时机获卵情况及后续冻融胚胎移植(FET)周期的妊娠结局。结果:患者的Gn使用天数、扳机日E2、取卵前日E2、MⅡ卵率组间比较差异均有统计学意义(P0.05)。取卵前日E2与扳机日E2相比上升者注射达菲林后33 h取卵获卵情况要差于35 h和36 h取卵者(P0.05),而取卵前日E2与扳机日E2相比下降者,下降比例≤1/3者获卵率要明显优于1/3者(P0.05)。结论:POR患者应用微刺激方案时,取卵前日E2与扳机日E2相比,上升者,可注射达菲林后35~36 h取卵;下降者,下降比例≤1/3,可33 h取卵,如下降比例1/3,则提示33 h后取卵获卵情况差。
[Abstract]:Aim: to investigate the more suitable timing of microstimulation in vitro fertilization / intracytoplasmic sperm microinjection-embryo transfer (IVF/ICSI-ET) for patients with low ovarian response to (poor ovarian. Methods: the clinical data of 363 cycles of POR patients who received IVF/ICSI-ET were analyzed retrospectively. They were divided into (CC) group (group A) and CC hMG group (group B). The patients were divided into two groups: (CC) group (group A) and group B (group B). The clinical and laboratory indexes were observed and analyzed. The oocytes were obtained at different time and the pregnancy outcome of the (FET) cycle of subsequent frozen-thawed embryo transfer was observed and analyzed. Results: there were significant differences in the days of Gn use, the trigger day E _ 2 and the egg rate of E _ 2 M 鈪，

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