来曲唑预防取卵术后卵巢过度刺激综合征的临床效果研究

发布时间：2018-08-22 07:06

【摘要】：目的:探讨卵巢过度刺激综合征(OHSS)高危人群在取卵术后,口服来曲唑预防OHSS发生的临床效果。方法:回顾性分析厦门市妇幼保健院2011年11月至2016年5月行体外受精-胚胎移植(IVF-ET)助孕,使用(GnRH-a)长方案或超长方案超促排卵,因预防OHSS取消移植,行全胚冷冻患者621例,按照是否于取卵术后口服来曲唑分为两组。一组于取卵术后未口服来曲唑(对照组),共298例;另一组于取卵术后口服来曲唑(研究组),共323例。对比两种方案患者助孕情况和OHSS的发生率、中重度OHSS的发生率。结果:研究组323例患者中OHSS的发生率为15.17%,显著低于对照组(P0.05)。研究组中重度OHSS的发生率为4.64%,也显著低于对照组(P0.05)。研究组促性腺激素(Gn)总量、Gn总天数、HCG日的雌二醇(E2)、黄体生成激素(LH)、孕酮(P)和获卵数与对照组比较差异无统计学意义(P0.05)。结论:来曲唑可以更好地降低高危人群在取卵术后OHSS的发生率及中重度OHSS的发生率。临床上可以考虑将来曲唑作为预防OHSS的药物使用。
[Abstract]:Objective: to investigate the clinical effect of oral letrozole on the prevention of OHSS after oocyte extraction in high risk population of ovarian hyperstimulation syndrome (OHSS). Methods: the in vitro fertilization and embryo transfer (IVF-ET) assisted pregnancy in Xiamen Maternal and Child Health Hospital from November 2011 to May 2016 were retrospectively analyzed. 621 cases of whole embryo cryopreservation were treated with long or super long (GnRH-a) regimen to induce ovulation. Letrazole was divided into two groups according to whether or not to take oral letrozole after oocyte extraction. One group received no oral letrozole (control group) and another group received letrozole (study group) 323 cases. The rate of pregnancy aid, OHSS and moderate and severe OHSS were compared between the two regimens. Results: the incidence of OHSS in the study group was 15.17, significantly lower than that in the control group (P0.05). The incidence of moderate and severe OHSS in the study group was 4.64 and significantly lower than that in the control group (P0.05). There was no significant difference in estradiol (E2), luteinizing hormone (LH), progesterone (P) and egg count between the study group and the control group (P0.05). Conclusion: letrozole can better reduce the incidence of OHSS and moderate to severe OHSS in high risk population. The future use of trazole as a prophylaxis of OHSS may be considered clinically.
【作者单位】：福建省厦门市妇幼保健院;
【基金】：福建省科技计划项目(编号:2015D018) 福建省卫生计生委青年科研课题(编号:2015-2-52)
【分类号】：R714.8

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