126例随访妊娠期妇女血清甲状腺激素参考值的研究

发布时间：2018-08-22 13:41

【摘要】：目的建立适合于在新疆医科大学第一附属医院就诊的妊娠期妇女血清甲状腺激素水平参考值,为来本院就诊的妊娠妇女甲状腺疾病的早期诊断和治疗提供临床依据。方法随访2015年3月~2015年12月在新疆医科大学第一附属医院就诊的健康妊娠期妇女126人,采用电化学发光分析方法检测其血清促甲状腺激素(TSH)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、甲状腺球蛋白抗体(Tg-Ab)和甲状腺过氧化物酶抗体(TPO-Ab)的浓度,血清甲状腺功能指标参考值制定方法采取美国临床生化研究院(NACB)推荐的方法,建立妊娠各期甲状腺激素水平参考范围。结果随访126名健康妊娠期妇女,得到了其血清FT3,FT4,TSH,TPO-Ab,Tg-Ab的参考值范围。其中血清FT3、FT4和TSH水平在妊娠各期之间的差异均有统计学意义(P0.001),与目前实验室使用的正常非孕女性的参考值之间的差异有统计学意义。正常非孕女性与妊娠期妇女各期的血清TPO-Ab和Tg-Ab水平差异无统计学意义(P0.05)。结论获得了新疆医科大学第一附属医院妊娠期妇女甲状腺激素参考值范围。故各地区应建立本地区或本单位的妊娠期甲状腺参考值范围,以利于对妊娠妇女甲状腺疾病进行筛查,利于早期诊断和治疗。
[Abstract]:Objective to establish the reference value of serum thyroid hormone level of pregnant women in the first affiliated Hospital of Xinjiang Medical University, and to provide clinical basis for the early diagnosis and treatment of thyroid diseases of pregnant women. Methods A total of 126 healthy pregnant women were followed up from March 2015 to December 2015 in the first affiliated Hospital of Xinjiang Medical University. The concentrations of serum thyroid stimulating hormone (TSH), free triiodothyronine (FT3), free thyroxine (FT4), thyroglobulin antibody (Tg-Ab) and thyroid peroxidase antibody (TPO-Ab) were determined by electrochemiluminescence (ECL). The reference value of serum thyroid function index was established by the method recommended by the American Institute of Clinical Biochemistry (NACB) to establish the reference range of thyroid hormone level during pregnancy. Results 126 healthy pregnant women were followed up and the reference range of TPO-AbTg-Ab was obtained. There were significant differences in serum FT _ 3 FT _ 4 and TSH levels between pregnant women and normal non-pregnant women (P0. 001). There was no significant difference in serum TPO-Ab and Tg-Ab levels between normal nonpregnant women and pregnant women (P0.05). Conclusion the reference range of thyroid hormone in pregnant women in the first affiliated Hospital of Xinjiang Medical University was obtained. Therefore, the reference value range of thyroid gland in pregnancy should be established in each area or unit in order to screen thyroid diseases in pregnant women and to diagnose and treat thyroid diseases in early stage.
【作者单位】：新疆医科大学公共卫生学院;新疆医科大学第一附属医院医学检验中心;
【分类号】：R714;R446.6

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