子宫颈腺癌中HPV感染与发病年龄的临床分析

发布时间：2018-08-22 19:30

【摘要】：目的探讨子宫颈腺癌中人乳头状瘤病毒(human papillomavirus,HPV)型别感染及其与发病年龄的关系。方法收集江西省妇幼保健院存档的子宫颈腺癌标本120例,采用三明治技术进行蜡块切片,应用SPF10-PCR技术进行DNA扩增,使用反向杂交线型探针检测技术(Li PA)的方法进行HPV分型,对所有切片进行病理阅片和诊断,分析子宫颈腺癌标本的HPV感染情况。结果 120例子宫颈腺癌标本中,HPV阳性率为77.5%(93/120)。子宫颈腺癌中HPV 16、18均为其主要型别,HPV16、18在子宫颈腺癌HPV阳性患者中均占43.01%(40/93)。感染HPV 16、18患者的平均年龄分别为43.41、41.06岁,感染HPV其他型别的患者平均年龄为46.85岁,差异有统计学意义(F=3.58,P=0.032)。结论 HPV 16、18为子宫颈腺癌的主要型别,腺癌中HPV 18感染的患者较其他型别感染的年龄小。
[Abstract]:Objective to investigate the relationship between human papillomavirus type infection and onset age in cervical adenocarcinoma. Methods 120 cases of cervical adenocarcinoma were collected from Jiangxi Maternal and Child Health Care Hospital. Paraffin sections were made by sandwich technique, DNA amplification was performed by SPF10-PCR technique, and HPV typing was carried out by reverse hybridization linear probe detection technique (Li PA). Pathological examination and diagnosis of all sections were performed to analyze HPV infection in cervical adenocarcinoma specimens. Results the positive rate of HPV was 77.5% (93 / 120) in 120 cases of cervical adenocarcinoma. HPV 16 ~ (16) ~ (18) was the main type of cervical adenocarcinoma, which accounted for 43.01% (40 / 93) of HPV positive patients in cervical adenocarcinoma. The average age of patients infected with HPV 16M was 43.41 / 41.06 years old, and the average age of patients infected with other types of HPV was 46.85 years old. The difference was statistically significant (F = 3.58, P < 0.032). Conclusion HPV 16 ~ (18) is the main type of cervical adenocarcinoma, and the patients infected with HPV _ (18) in adenocarcinoma are younger than those with other types of infection.
【作者单位】：江西省妇幼保健院医务科;江西省妇幼保健院病理科;
【分类号】：R737.33

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