子痫前期预测指标的临床应用研究进展

发布时间：2018-08-24 09:17

【摘要】：子痫前期与孕产妇及其围生期发病率和病死率的增加关系密切。孕产妇子痫前期发病风险的早期识别可以有效地加强其孕期管理。预测子痫前期的监测方法包括临床病史、体格检查、实验室检查和血流动力学检查。一般来说,孕早期预测子痫前期发展的特异度好于敏感度,如:体质量指数(BMI)大于34 kg/m2、甲胎蛋白、纤连蛋白和子宫动脉多普勒(双侧)的特异度均超过90%。只有子宫动脉阻力指数和结合指数的敏感度超过60%。尿激肽释放酶等检查项目,在不考虑特异度的情况下具有高达80%以上的敏感度,但是其临床应用需要进一步的研究。目前,临床实践中子痫前期的预测多是几项检查指标的联合应用,没有一项检查项目具有足够的精确度可以独立使用。
[Abstract]:Preeclampsia is closely related to the increase of morbidity and mortality of pregnant women and their perinatal period. Early identification of maternal preeclampsia risk can effectively strengthen their pregnancy management. Monitoring methods for predicting preeclampsia include clinical history, physical examination, laboratory and hemodynamic examination. In general, the specificity of early pregnancy in predicting preeclampsia is better than that of sensitivity. For example, the body mass index (BMI) is greater than 34 kg/m2, alpha fetoprotein, fibronectin and uterine artery Doppler (bilateral) are more than 90%. Only uterine artery resistance index and binding index were more sensitive than 60. Urinary kallikrein and other tests have a sensitivity of more than 80% without considering the specificity, but its clinical application needs further study. At present, the prediction of preeclampsia in clinical practice is mostly a combination of several examination indicators, none of which has enough accuracy to be used independently.
【作者单位】：天津医科大学;天津市中心妇产科医院;
【分类号】：R714.244

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